PMID: 697082Oct 1, 1978Paper

Epidural anesthesia with bupivacaine for Cesarean section: neonatal blood levels and neurobehavioral responses

Anesthesiology
G A McGuinnessA Erenberg

Abstract

A recent study found no neurobehavioral change in infants whose mothers received bupivacaine epidural anesthesia (112 +/- 7 mg) for labor and vaginal delivery. The present study was undertaken to examine the possibility that the larger doses of bupivicaine necessary for cesarean section might cause neurobehavioral changes in the neonate. Ten infants delivered by cesarean section with bupivacaine epidural anesthesia (168 +/- 7 mg) was assessed by Scanlon's neonatal neurobehavioral examination. They were compared in a prospective randomized study with a control group of ten infants delivered with tetracaine spinal anesthesia. In the experimental group bupivacaine was detectable in umbilical arterial blood (.17 +/- .07 microgram/ml), umbilical venous blood (.21 +/- .09 microgram/ml), and neonatal blood samples at 4 hours of age (.04 +/- .04 microgram/ml). By 24 hours of age bupivacaine was no longer detectable in newborn blood samples. Infants in the experimental group were indistinguishable from control infants in terms of their motor organization, responsiveness to external stimuli, and habituation to repetitive stimuli. Detectable neurobehavioral effects were absent despite the fact that 1.5 times the dose of bupivacaine used f...Continue Reading

Citations

Oct 31, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·M van de VijverN Aladangady
Jan 1, 1992·International Journal of Obstetric Anesthesia·S A Lassos, S Datta
Aug 1, 1995·Pharmacology & Toxicology·T I Ala-KokkoK Vähäkangas
Jul 1, 1979·Scottish Medical Journal·D D Moir
Jul 27, 2017·Wiener medizinische Wochenschrift·Maximiliaan van ErpKlaus Ulrich Klein
Jul 1, 1982·Anaesthesia·I Corall
Jan 1, 1986·Annales Françaises D'anesthèsie Et De Rèanimation·J P Haberer, C Monteillard

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