Epidural cooling for the prevention of ischemic injury to the spinal cord during aortic occlusion in a rabbit model: determination of the optimal temperature

Journal of Vascular Surgery
Eugenio MartelliPeter Gloviczki

Abstract

This experiment was designed for the determination of the optimal epidural cooling temperature for the allowance of spinal cord protection with minimal side effects during an aortic occlusion-induced spinal cord ischemia model in rabbits. Spinal cord ischemia was induced in rabbits with infrarenal aortic occlusion for 40 minutes. Spinal cord cooling was effected with epidural infusion of normal saline solution at the following different temperatures: group 1, 17 degrees C (n = 6); group 2, 24 degrees C (n = 6); group 3, 32 degrees C (n = 6); and group 4, 39 degrees C (n = 3). Sham-operated rabbits without aortic occlusion were used as controls with epidural infusion at healthy body temperature (39 degrees C; n = 3). Motor function was assessed at 48 hours with Tarlov's criteria, and the animals were killed. The spinal cord was sectioned into multiple segments, and semiquantitative histologic scoring (0 to 5) was used to grade ischemic injury. Cooling solution and spinal cord temperatures showed linear correlation (r = 0.95). All the rabbits in groups 1 (except one with mild weakness), 2, and 3 were neurologically intact, and all in group 4 had paraplegia develop (P < .001). One rabbit in group 1 died from increased intracranial...Continue Reading

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Citations

Dec 18, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hideyuki ShimizuRyohei Yozu
Jul 7, 2012·AJNR. American Journal of Neuroradiology·P D PurdyM S Riegel
Mar 31, 2011·General Thoracic and Cardiovascular Surgery·Hideyuki Shimizu, Ryohei Yozu
Jan 29, 2005·The Journal of Thoracic and Cardiovascular Surgery·Enyi ShiHitoshi Terada
Jun 24, 2008·Journal of Vascular Surgery·Satoshi AkuzawaHitoshi Terada
Sep 1, 2012·Therapeutic Hypothermia and Temperature Management·Hamdy AwadPhillip G Popovich

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