Abstract
To determine the extent of enhanced blockade by the combined use of epidural fentanyl and mepivacaine. We compared the onset of hypoalgesia, analgesia and the threshold of pressure pain. Thirty patients were randomly divided into three groups. The fentanyl group received 10 ml saline containing 0.1 mg fentanyl, mepivacaine group received 10 ml mepivacaine 1% and a mixed group received 10 ml mepivacaine 1% with 0.1 mg fentanyl. All solutions, without epinephrine, were injected through an epidural catheter at T5-6 to T6-7. The change in sensation, loss of pin-prick and pain threshold sensation, measured by pressure algometer, were assessed at 2.5-min intervals for 15 min at the T4 dermatome. Spread of analgesia was determined at 15 min. Loss of pinprick was more rapid in the mixed, 11.0 +/- 2.7 (SD) min, than in the mepivacaine group, 15.0 +/- 2.9 min, (P < 0.05), although there was no difference in change of sensation. Pressure pain threshold increased with time in the mepivacaine (P < 0.05) and mixed (P < 0.05) groups. It was higher in the mixed than in the fentanyl and mepivacaine groups at 5, 7.5 and 10 min (P < 0.05). The lower level of analgesia was lower in the mixed than in the mepivacaine groups (P < 0.05). Blood pressur...Continue Reading
References
Jul 11, 1975·Experimental Brain Research·C J Game, D Lodge
May 1, 1992·Anaesthesia·K A GeorgeG A Browne
Jun 1, 1991·British Journal of Anaesthesia·D W NobleJ H McClure
Jun 25, 1990·Brain Research·D BesseJ M Besson
Feb 1, 1990·Anaesthesia and Intensive Care·M J PaechH M Speirs
Apr 1, 1990·Anaesthesia·M J KingG M Cooper
Sep 1, 1987·Anesthesiology·S E CohenJ Halpern
Feb 1, 1986·Pain·Anthony H Dickenson, Ann F Sullivan
Mar 1, 1985·British Journal of Anaesthesia·F S RucciP Migliori
Nov 19, 1965·Science·R Melzack, P D Wall
Jul 1, 1980·Anesthesia and Analgesia·P R BromageD Chestnut
Sep 1, 1984·Anesthesiology·M J Cousins, L E Mather
Feb 25, 1982·Brain Research·T Doi, I Jurna
Nov 1, 1993·Acta Anaesthesiologica Scandinavica·P M HalonenK Korttila
May 1, 1993·British Journal of Anaesthesia·D W Cooper, G Turner
Dec 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G GaggeroK Rifat
Citations
Nov 7, 1998·Journal of Clinical Anesthesia·M Arakawa, S Hoka
Dec 17, 2014·Journal of Postgraduate Medicine·L H ParateB Manjunath
Nov 23, 2005·Anesthesia and Analgesia·Chen-Hwan CherngChih-Shung Wong