PMID: 18717511Aug 23, 2008Paper

Epidural haloperidol enhances epidural morphine analgesia: three case reports

Journal of Opioid Management
George ColcloughP Steyn

Abstract

Epidural opioids provide significant postoperative analgesia; however, their use is often limited by side effects such as nausea and pruritus, or they require the addition of epidural local anesthetics with possible side effects of motor block and hypotension. Adjuncts to epidural opioid analgesia would benefit pain management. There is evidence that epidural butyrophenones may enhance opioid analgesics and reduce side effects. The authors present the first reported use of epidural haloperidol to enhance epidural morphine analgesia in three individuals. Pharmacodynamic interactions of haloperidol, which may explain its analgesic efficacy, are summarized.

Citations

Apr 6, 2013·Journal of Palliative Medicine·Shelley R SalpeterEduardo Bruera
Mar 19, 2013·European Journal of Pharmacology·Daniel ZamanilloJosé Miguel Vela
Jun 25, 2017·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Carlos J RoldanYashwant Chathampally
Jun 4, 2015·Expert Opinion on Investigational Drugs·José Miguel VelaCarmen Almansa
Jun 4, 2015·Expert Opinion on Drug Discovery·Mellar P Davis
Dec 11, 2014·Journal of Palliative Medicine·Shelley R SalpeterEduardo Bruera

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

The Orthopedic Clinics of North America
Raymond TangChristopher Kim
Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Andrew Choyce, Philip Wh Peng
The Canadian Veterinary Journal. La Revue Vétérinaire Canadienne
Kip A Lemke
© 2022 Meta ULC. All rights reserved