Epidural intracranial pressure measurement in rats using a fiber-optic pressure transducer.

Journal of Visualized Experiments : JoVE
Lucy MurthaNeil Spratt

Abstract

Elevated intracranial pressure (ICP) is a significant problem in several forms of ischemic brain injury including stroke, traumatic brain injury and cardiac arrest. This elevation may result in further neurological injury, in the form of transtentorial herniation(1,2,3,4), midbrain compression, neurological deficit or increased cerebral infarct(2,4). Current therapies are often inadequate to control elevated ICP in the clinical setting(5,6,7). Thus there is a need for accurate methods of ICP measurement in animal models to further our understanding of the basic mechanisms and to develop new treatments for elevated ICP. In both the clinical and experimental setting ICP cannot be estimated without direct measurement. Several methods of ICP catheter insertion currently exist. Of these the intraventricular catheter has become the clinical 'gold standard' of ICP measurement in humans(8). This method involves the partial removal of skull and the instrumentation of the catheter through brain tissue. Consequently, intraventricular catheters have an infection rate of 6-11%(9). For this reason, subdural and epidural cannulations have become the preferred methods in animal models of ischemic injury. Various ICP measurement techniques have...Continue Reading

Citations

Jul 18, 2015·Sensors·Sven PoeggelElfed Lewis
Sep 13, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·L A MurthaN J Spratt
Dec 2, 2015·Journal of Biomechanics·Mehran MoazenSusan W Herring
Feb 14, 2014·Journal of Neuroscience Methods·Maria UldallRigmor Jensen
Dec 23, 2015·International Journal of Molecular Sciences·Usmah KawoosMikulas Chavko
Jul 15, 2015·Journal of Applied Physiology·Sarah-Jane GuildSimon C Malpas
Nov 27, 2019·Fluids and Barriers of the CNS·Sajedeh EftekhariRigmor Hoejland Jensen

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