PMID: 3752551Oct 1, 1986Paper

Epidural morphine improves pain relief and maintains sensory analgesia during continuous epidural bupivacaine after abdominal surgery

Anesthesia and Analgesia
N C HjortsøH Kehlet

Abstract

Twenty patients scheduled for elective major abdominal surgery were matched into two groups with regard to age, sex, height, body weight, and surgical procedure. Both groups received general anesthesia plus lumbar epidural analgesia with similar loading doses of bupivacaine 0.5% (23.1 +/- 1.0 and 23.3 +/- 0.8 ml) (mean +/- SEM) followed by continuous infusion of plain bupivacaine 0.5% (8 ml/hr) plus, in one group, epidural morphine (0.5 mg/hr). Pain score on a 5-point scale and sensory analgesia (pin prick) were assessed hourly for 16 hours after skin incision. If sensory analgesia decreased more than 5 segments from preoperative levels or if pain scores reached 2 (moderate pain), the patients were removed from the study, and pain was treated with other methods. Preoperative mean (+/- SEM) sensory levels of analgesia were similar in the bupivacaine and the bupivacaine-morphine groups (T3.4 +/- 0.5 and T3.3 +/- 0.4, respectively). In the group receiving only bupivacaine, sensory analgesia regressed over time with a simultaneous increase in pain score. Thus, within 10 hr after skin incision, seven patients in this group were discharged from the study, and 16 hr after incision only one patient maintained initial level of sensory a...Continue Reading

Citations

May 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F B SevarinoR S Sinatra
Apr 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N H Badner, W E Komar
May 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N H BadnerW E Komar
Apr 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S St-OngeM Girard
Jul 1, 1990·Journal of Anesthesia·S SakuraY Kosaka
May 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·B Morgan
Jun 3, 1999·The Surgical Clinics of North America·D S Stevens, W T Edwards
Nov 13, 2001·Journal of Clinical Anesthesia·F Jin, F Chung
Aug 1, 1991·Acta Anaesthesiologica Scandinavica·R AsantilaP H Rosenberg
Jan 1, 1992·Acta Anaesthesiologica Scandinavica·J MourisseG J Cromheecke
Jan 1, 1994·Acta Anaesthesiologica Scandinavica·L Quist ChristensenJ P Kampmann
Dec 4, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G OzalpN Kadiogullari
Sep 22, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Akifumi KanaiSumio Hoka
Mar 15, 2011·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·Louise RoseJudy Watt-Watson
Oct 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·C J O'Connor
Jun 1, 1990·Journal of Cardiothoracic Anesthesia·D L Brown, R L Carpenter
Jan 1, 1991·Annales Françaises D'anesthèsie Et De Rèanimation·P Scherpereel
Aug 1, 1987·American Journal of Surgery·R RaggiA L Mauro
Jul 20, 2001·British Journal of Anaesthesia·R G WheatleyD Watson

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