Epidural oxycodone or morphine following gynaecological surgery

British Journal of Anaesthesia
F Yanagidate, S Dohi

Abstract

The analgesic action of oxycodone is of rapid onset, in contrast to morphine, and is mediated by kappa-opioid receptors of the spinal cord. We compared analgesia and side-effects of epidural oxycodone with those of morphine after gynaecological surgery. We studied prospectively in 75 women in a double-blind, randomized manner: epidural morphine 6 mg day(-1) (n=25), epidural oxycodone 6 mg day(-1) (n=25) and epidural oxycodone 12 mg day(-1) (n=25). All patients underwent gynaecological surgery under general (isoflurane and nitrous oxide) and epidural anaesthesia. Visual analogue scale (VAS) pain scores at rest and on coughing, verbal descriptive scale (VDS) satisfaction scores, sedation scores, pruritus scores and nausea/vomiting scores were recorded for 3 days after surgery. VAS pain scores at rest in patients who received oxycodone 6 mg day(-1) were higher than in patients who received morphine 6 mg day(-1) at 6 h and on the first postoperative day and were significantly higher than in patients who received oxycodone 12 mg day(-1) on the first postoperative day. Scores for nausea, vomiting and pruritus in patients who received oxycodone 6 mg day(-1) and 12 mg day(-1) were lower than those in patients who received morphine. No ...Continue Reading

References

Oct 1, 1991·Acta Anaesthesiologica Scandinavica·E KalsoT Tammisto
May 1, 1990·Clinical Pharmacology and Therapeutics·E Kalso, A Vainio
May 1, 1982·British Journal of Anaesthesia·L L GustafssonK Jacobsen
Jan 1, 1994·Pharmacology & Toxicology·R Pöyhiä, T Seppälä
Oct 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M A Chaney
Feb 1, 1997·Journal of Clinical Anesthesia·M BacklundP H Rosenberg
Jul 28, 1999·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·B GagnonE Bruera

❮ Previous
Next ❯

Citations

Feb 12, 2013·Journal of Anesthesia·Mustafa Said AydoganCemil Colak
Apr 24, 2012·Expert Opinion on Pharmacotherapy·Hannu KokkiSari Sjövall
Apr 21, 2006·Expert Review of Neurotherapeutics·Gabriela Rocha Lauretti
May 27, 2008·Journal of Clinical Anesthesia·William R KimballJane C Ballantyne
May 13, 2011·European Journal of Anaesthesiology·Christopher J JankowskiJuraj Sprung
Jan 30, 2008·Anesthesia and Analgesia·Kim K LembergEija A Kalso
Nov 13, 2019·The Clinical Journal of Pain·Heying Y ZhongShu Cai
Jan 18, 2019·Clinical Pharmacokinetics·Mari KinnunenMerja Kokki
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Xavier Basurto OnaXavier Bonfill Cosp
Nov 12, 2020·Canadian Journal of Physiology and Pharmacology·Cheng-Wei LuSu-Jane Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.