PMID: 8601886Mar 1, 1996Paper

Epidural regional hypothermia for prevention of paraplegia after aortic occlusion: experimental evaluation in a rabbit model

Journal of Vascular Surgery
J Gonzalez-FajardoC Vaquero

Abstract

The efficacy of epidural regional hypothermia in the prevention of acute and delayed-onset paraplegia, as well as possible complications and limitations of this technique to a clinically acceptable form, were evaluated in 49 New Zealand white rabbits. A modified rabbit spinal cord ischemia model of infrarenal aortic occlusion for 30 minutes was employed. The study was performed in two phases. In phase I (n=20), regional hypothermia induced by epidural perfusion of iced normal saline solution (4 degrees C) was tested versus control in 10 rabbits each (groups A and B). In phase II (n=29) the animals were subdivided into three groups to study the kinetics of absorbtion and distribution of methylene blue (group C; n=10), radiographic contrast material (group D; n=9), and measurement of cerebrospinal pressure while an epidural iced solution was or was not infused (group E; n=10). At 24 and 48 hours, all of the normothermic animals showed irreversible paraplegia (Tarlov score 0). In contrast, at 24 hours none of the rabbits undergoing epidural cold infusion were paraplegic, although at 48 hours one animal had weakness of a hindlimb (Tarlov score 3). Plasma concentration-time profiles of a continuous epidural perfusion with methylene ...Continue Reading

References

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Citations

Aug 2, 2000·The Annals of Thoracic Surgery·S A MeylaertsM J Jacobs
Sep 6, 2003·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Omer CakirNesimi Eren
Sep 1, 2012·Therapeutic Hypothermia and Temperature Management·Hamdy AwadPhillip G Popovich
Oct 18, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Koji TsutsumiShiaki Kawada
Oct 30, 2004·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Koji TsutsumiRyohei Yozu
Aug 5, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D A CooleyO H Frazier
Jul 2, 2014·The Journal of Surgical Research·Ramez AntakiaSaba P Balasubramanian

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