Epidural verapamil reduces analgesic consumption after lower abdominal surgery

Anesthesia and Analgesia
H ChoeH S Song

Abstract

In this double-blind study, we administered lumbar epidural bupivacaine or bupivacaine plus verapamil to investigate the possible role of the calcium channel blocker, verapamil, in postoperative pain. One hundred patients (ASA physical class I or II) scheduled for lower abdominal surgery were randomly assigned to one of four groups. Group 1 received 10 mL of 0.5% epidural bupivacaine injected 15 min before incision, followed by 10 mL of epidural normal saline 30 min after incision. Group 2 received 10 mL of epidural normal saline injected before incision, followed by 10 mL of 0.5% epidural bupivacaine 30 min after incision. Group 3 received 10 mL of 0.5% epidural bupivacaine plus 5 mg of verapamil injected before incision, followed by 10 mL of epidural normal saline 30 min after incision. Group 4 received the same drugs as Group 3, in the reverse order. Pain and mood numeric rating scores, sedation scores, Prince Henry scores, patient-controlled cumulative postoperative analgesic consumption, and the incidence of side effects were assessed 2, 6, 12, 24, and 48 h after the operation in each group. Cumulative postoperative analgesic consumption in Groups 3 and 4 was significantly lower (P < 0.05) than that in Groups 1 and 2 24 an...Continue Reading

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Citations

Aug 10, 2000·Anesthesiology Clinics of North America·J C Crews
Nov 7, 2000·Acta Anaesthesiologica Scandinavica·V Dahl, J C Raeder
Feb 5, 2002·Clinical Pharmacokinetics·Jorn LotschGerd Geisslinger
Jul 28, 2004·Anesthesiology·Steven P CohenSalahadin Abdi
May 22, 2007·Anesthesia and Analgesia·Paul F WhiteUNKNOWN Fast-Track Surgery Study Group
Jan 24, 2006·Anesthesia and Analgesia·Gerri CaseyD J Buggy
Apr 20, 2002·American Journal of Physical Medicine & Rehabilitation·Chuen-Ru HouChang-Zern Hong
Dec 22, 1999·Anesthesiology·P M Dougherty, P S Staats

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