Epigallocatechin-3-gallate induces apoptosis, inhibits proliferation and decreases invasion of glioma cell

Neuroscience Bulletin
Hong LiFu-Xue Chen

Abstract

Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, has been considered a potential therapeutic and chemopreventive agent for cancer. Glioma is a malignant tumor with high mortality but effective therapy has not yet been developed. In this study, we found that EGCG induced apoptosis in U251 glioma cells via the laminin receptor (molecular weight 67 kDa) in a time- and dose-dependent manner, decreased their invasiveness and inhibited their proliferation. The mitogen-activated protein kinase pathway was shown to be involved in glioma cell apoptosis and proliferation. Furthermore, the mRNA levels of matrix metalloproteinase (MMP)-2 and MMP-9 were reduced after EGCG treatment. These results suggest that EGCG has important therapeutic effects with low toxicity and side-effects, and could be used in cancer chemoprevention.

References

Mar 29, 1983·Biochemical and Biophysical Research Communications·N C RaoL A Liotta
May 1, 1983·The Journal of Cell Biology·H L Malinoff, M S Wicha
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·K GohjiM Nakajima
Jan 11, 2001·The New England Journal of Medicine·L M DeAngelis
Apr 3, 2001·Annual Review of Neuroscience·R Wechsler-Reya, M P Scott
Jun 8, 2001·Genes & Development·E A MaherR A DePinho
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
May 7, 2003·Biochemical and Biophysical Research Communications·Yun-Jung ChoiTaeg-Kyu Kwon
Mar 17, 2004·Nature Structural & Molecular Biology·Hirofumi TachibanaKoji Yamada
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Jul 28, 2007·Life Sciences·Naghma Khan, Hasan Mukhtar
Dec 7, 2007·Cancer Biology & Therapy·Rajesh L ThangapazhamRadha K Maheshwari

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Citations

Aug 26, 2016·International Journal of Cancer. Journal International Du Cancer·Takahiro OgawaUNKNOWN Japan Public Health Center-Based Prospective Study Group
Oct 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marko VidakRadovan Komel
Jul 14, 2017·Frontiers in Molecular Neuroscience·Libo SaYixue Xue
Jul 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saleh A AlmatroodiArshad Husain Rahmani
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayesha Atiq, Ishwar Parhar
Feb 2, 2021·Oncotarget·Gina Abdelaal, Stephany Veuger
Aug 10, 2020·Mini Reviews in Medicinal Chemistry·Amir R AfshariAmirhossein Sahebkar

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