Epigallocatechin-3-gallate protects toluene diisocyanate-induced airway inflammation in a murine model of asthma

FEBS Letters
Seung-Hun KimYeong-Min Park

Abstract

Epigallocatechin-3-gallate (EGCG), a major form of tea catechin, has anti-allergic properties. To elucidate the anti-allergic mechanisms of EGCG, we investigated its regulation of matrix metalloproteinase (MMP-9) expression in toluene diisocyanate (TDI)-inhalation lung tissues as well as TNF-alpha and Th2 cytokine (IL-5) production in BAL fluid. Compared with untreated asthmatic mice those administrated with EGCG had significantly reduced asthmatic reaction. Also, increased reactive oxygen species (ROS) generation by TDI inhalation was diminished by administration of EGCG in BAL fluid. These results suggest that EGCG regulates inflammatory cell migration possibly by suppressing MMP-9 production and ROS generation, and indicate that EGCG may be useful as an adjuvant therapy for bronchial asthma.

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Citations

Jun 14, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Seoung Ju ParkYong Chul Lee
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