Epigallocatechin gallate inhibits dimethylhydrazine-induced colorectal cancer in rats.

World Journal of Gastroenterology : WJG
Yu WangShui-Ming Wang

Abstract

Epigallocatechin gallate (EGCG) is a polyhydroxy phenolic compound extracted from tea and its antitumor effect has received widespread attention. We explored the inhibitory effect of EGCG on dimethylhydrazine (DMH)-induced colorectal cancer (CRC) using a rat model, predicted the interaction between EGCG and CRC target genes using a database, and explained the EGCG associated target pathways and mechanisms in CRC. To understand the inhibitory mechanisms of EGCG on CRC cell proliferation and identify its pharmacological targets by network pharmacology analysis. DMH (40 mg/kg, s.c., twice weekly for eight weeks) was used to induce CRC in rats. After model establishment, the rats were administered with EGCG (50, 100, or 200 mg/kg, p.o., once daily for eight weeks) and killed 12 and 20 wk after the start of the experiment. Formation of aberrant crypt foci and tumor was studied by histological analysis. Using network pharmacology analysis, candidate and collective targets of EGCG and CRC were identified, and Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses were used to predict the pathways altered by EGCG. At week 12, high-dose EGCG treatment significantly reduced the tumor formation rate, total number of tumor...Continue Reading

References

Jul 1, 1997·Japanese Journal of Cancer Research : Gann·S OkabeH Fujiki
Aug 5, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Ling Long, Qingwang Li
Apr 25, 2007·World Journal of Gastroenterology : WJG·Bao-He ZhuChang-Hua Zhang
Mar 30, 2010·Chemico-biological Interactions·Masahito ShimizuHisataka Moriwaki
Aug 24, 2010·International Journal of Colorectal Disease·Heiying JinYijiang Ding
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Mar 15, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chung S YangHuanyu Jin
Aug 27, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A CurrieR Kennedy
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Dec 3, 2014·Gastroenterology·Stephanie S Tseng-RogenskiJohn M Carethers
Oct 30, 2015·Gastroenterology Report·Preet Paul SinghA Craig Lockhart
Mar 22, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MalvezziE Negri

❮ Previous
Next ❯

Citations

Oct 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sumio HayakawaMamoru Isemura
Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Feiye ZhuGuanqun Xie
May 1, 2021·Veterinary Sciences·Elisabete Nascimento-GonçalvesPaula A Oliveira
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aline YammineNorbert Latruffe

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

R
String
edger R
Cytoscape
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.