Epigallocatechin Gallate/Layered Double Hydroxide Nanohybrids: Preparation, Characterization, and In Vitro Anti-Tumor Study

PloS One
Seyedeh Sara ShafieiNoor Azuan Abu Osman

Abstract

In recent years, nanotechnology in merging with biotechnology has been employed in the area of cancer management to overcome the challenges of chemopreventive strategies in order to gain promising results. Since most biological processes occur in nano scale, nanoparticles can act as carriers of certain drugs or agents to deliver it to specific cells or targets. In this study, we intercalated Epigallocatechin-3-Gallate (EGCG), the most abundant polyphenol in green tea, into Ca/Al-NO3 Layered double hydroxide (LDH) nanoparticles, and evaluated its efficacy compared to EGCG alone on PC3 cell line. The EGCG loaded LDH nanohybrids were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy (TEM) and nanosizer analyses. The anticancer activity of the EGCG-loaded LDH was investigated in prostate cancer cell line (PC3) while the release behavior of EGCG from LDH was observed at pH 7.45 and 4.25. Besides enhancing of apoptotic activity of EGCG, the results showed that intercalation of EGCG into LDH can improve the anti- tumor activity of EGCG over 5-fold dose advantages in in-vitro system. Subsequently, the in-vitro release data showed that EGCG-loaded LDH had longer release duratio...Continue Reading

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Citations

May 24, 2016·Nutrients·Andreia GranjaSalette Reis
Jun 3, 2016·Chemistry Central Journal·Ajona MegalathanNilwala Kottegoda
Sep 1, 2016·ACS Applied Materials & Interfaces·Naijian GeXuanyong Liu
Dec 23, 2016·Medicinal Research Reviews·Yuee CaiMeiwan Chen
Feb 28, 2016·Journal of the Science of Food and Agriculture·Katja IsteničNataša Poklar Ulrih
Oct 1, 2016·International Journal of Molecular Sciences·Edward RwegasilaJoan J E Munissi
Mar 10, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haseeb ZubairAjay Pratap Singh
Dec 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mei ZhangNorbert Radacsi

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Methods Mentioned

BETA
transmission electron microscopy
ELISA
fluorescence microscopy
infrared spectroscopy

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