Abstract
Epigenetic age acceleration-the difference between an individual's DNA methylation age and chronological age-is associated with many diseases including cancer. This study aims to evaluate epigenetic age acceleration as a prognostic biomarker for gliomas. DNA methylation data of gliomas patients (516 low-grade and intermediate-grade gliomas and 140 glioblastoma) were obtained from The Cancer Genome Atlas (TCGA) and patient epigenetic ages were computed using Horvath's age prediction model. We used multivariate linear regression to assess the association of epigenetic age acceleration with tumor molecular subtypes, including Codel, Classic-like, G-CIMP-high, G-CIMP-low, Mesenchymal-like and PA-like. Compared with Codel subtype, epigenetic ages in other molecular subtypes show deceleration after controlling age and race. Age deceleration for Classic-like, G-CIMP-high, G-CIMP-low, Mesenchymal-like and PA-like were 15.42 years (CI: 7.98-22.86, p = 5.38E-05), 25.00 years (CI: 20.79-29.22, p = 4.06E-28), 28.56 years (CI: 14.37-42.74, p = 8.75E-05), 45.34 years (CI: 38.80-51.88, p = 2.15E-36), and 53.58 years (CI: 44.90-62.26, p = 4.81E-30), respectively. Then, Cox proportional hazards regression was used to assess the association of e...Continue Reading
References
Oct 17, 1998·Journal of the National Cancer Institute·J G CairncrossD N Louis
Feb 28, 2003·Surgery·Shinichi TsutsuiYoichi Hachitanda
Sep 6, 2008·Science·D Williams ParsonsKenneth W Kinzler
Aug 15, 2009·PLoS Genetics·Brock C ChristensenKarl T Kelsey
Apr 28, 2011·Journal of Neuro-oncology·Robert A OlsonDavid A Palma
May 27, 2011·Genome Research·Agustin F FernandezManel Esteller
Jul 7, 2011·PloS One·Sven BocklandtEric Vilain
Nov 10, 2011·Aging·Carmen M Koch, Wolfgang Wagner
Oct 20, 2012·Cancer Cell·Dominik SturmStefan M Pfister
Nov 28, 2012·Molecular Cell·Gregory HannumKang Zhang
May 11, 2013·Acta Neuropathologica·Sally R LambertDavid T W Jones
May 18, 2013·Frontiers of Medicine·Chuanbao ZhangTao Jiang
May 22, 2013·Acta Neuropathologica·Pilar MurBárbara Meléndez
Oct 19, 2013·Human Molecular Genetics·Joseph L McClayEdwin J C G Van Den Oord
Oct 22, 2013·Genome Biology·Steve Horvath
Feb 5, 2014·Genome Biology·Carola Ingrid WeidnerWolfgang Wagner
Jul 24, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jigisha P ThakkarJohn L Villano
Jan 31, 2015·Genome Biology·Riccardo E MarioniIan J Deary
Feb 14, 2015·Aging Cell·Steve HorvathClaudio Franceschi
Jun 26, 2015·PLoS Genetics·Qiong Lin, Wolfgang Wagner
Nov 26, 2015·Aging Cell·Lene ChristiansenKaare Christensen
Dec 15, 2015·Aging·Steve Horvath, Beate R Ritz
Dec 20, 2015·Aging·Morgan E LevineSteve Horvath
Jan 30, 2016·Cell·Michele CeccarelliRoel G W Verhaak
Jun 9, 2016·Clinical Epigenetics·Laura PernaHermann Brenner
Jul 2, 2016·JAMA Oncology·Daniel E SprattJoseph R Osborne
Oct 1, 2016·Aging·Brian H ChenSteve Horvath
Mar 11, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ricky ChenHoward Colman
Mar 16, 2017·Clinical Epigenetics·Tapio NevalainenMikko Hurme
May 1, 2017·Ageing Research Reviews·Eva Latorre, Lorna W Harries
Jun 3, 2017·Cancer Discovery·UNKNOWN AACR Project GENIE Consortium
Nov 25, 2017·Seminars in Cancer Biology·Olga Gusyatiner, Monika E Hegi
Dec 3, 2017·International Journal of Cancer. Journal International Du Cancer·Pierre-Antoine DuguéRoger L Milne
Feb 13, 2018·Neuro-oncology·Peter LiaoJill S Barnholtz-Sloan
Feb 28, 2018·International Journal of Radiation Oncology, Biology, Physics·Erin S MurphyManmeet S Ahluwalia
Aug 1, 2018·Lancet·Sarah LapointeNicholas A Butowski
Sep 12, 2018·Cancers·Ying ZhangRoger Abounader
Oct 20, 2018·BMC Cancer·Jun-Ting RenZe-Fang Ren
Aug 4, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chunlei ZhengRong Xu