Epigenetic alterations associated with childhood trauma and adult mental health outcomes: A systematic review.

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Jani NöthlingSoraya Seedat

Abstract

Objectives: Multiple, chronic and repeated trauma exposure in childhood is associated with adverse mental health outcomes in adulthood. In this paper we synthesise the literature on epigenetic modifications in childhood trauma (CT) and the mediating effects of differential epigenetic mechanisms on the association between CT and the later onset of psychiatric disorders.Methods: We reviewed the literature up to March 2018 in four databases: PubMed, Web of Science, EBSCOhost and SCOPUS. Non-human studies were excluded. All studies investigating CT exposure both in healthy adults (18 years and older) and adults with psychiatric disorders were included.Results: Thirty-six publications were included. For mood disorders, methylation of the glucocorticoid receptor NR3C1 gene, specifically at the NGFI-A binding site in exon 1F, and correlation with CT was a robust finding. Several studies documented differential methylation of SLC6A4, BDNF, OXTR and FKBP5 in association with CT. Common pathways identified include neuronal functioning and maintenance, immune and inflammatory processes, chromatin and histone modification, and transcription factor binding.Conclusions: A variety of epigenetic mediators that lie on a common pathway between C...Continue Reading

References

Dec 26, 2001·Biological Psychiatry·V G CarrionA L Reiss
Apr 13, 2002·Biological Psychiatry·Michael D De BellisJulie Hall
Apr 18, 2002·Biological Psychiatry·Gabriele S LeverichRobert M Post
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
Sep 25, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Bernd FrankGudrun Rappold
Apr 2, 2005·Nature Reviews. Genetics·David J Hunter
Aug 19, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Huaibin CaiPhilip C Wong
Jun 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·R S DevonM R Hayden
Aug 29, 2006·Biological Psychiatry·Michael D De Bellis, Maragatha Kuchibhatla
Feb 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ian C G WeaverMichael J Meaney
Apr 25, 2007·Nature Reviews. Neuroscience·Nadia TsankovaEric J Nestler
Oct 9, 2007·Acta Psychiatrica Scandinavica·A Uçok, S Bikmaz
Oct 12, 2007·Psychological Medicine·Jelena BrezoGustavo Turecki
Nov 16, 2007·Pflügers Archiv : European journal of physiology·Nael Nadif Kasri, Linda Van Aelst
Mar 8, 2008·Trends in Genetics : TIG·Stephan Beck, Vardhman K Rakyan
Mar 19, 2008·Molecular Psychiatry·L PezawasD R Weinberger
Jun 10, 2008·Epigenetics : Official Journal of the DNA Methylation Society·Tim F OberlanderAngela M Devlin
Jul 8, 2008·Psychoneuroendocrinology·Christine HeimCharles B Nemeroff
Sep 20, 2008·CNS Neuroscience & Therapeutics·Elizabeth A HogeNaomi M Simon
Oct 30, 2008·Molecular Psychiatry·C HeimC B Nemeroff
Jan 24, 2009·Psychiatry Research·Audrey R TyrkaLinda L Carpenter
Feb 24, 2009·Nature Neuroscience·Patrick O McGowanMichael J Meaney
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Aug 6, 2009·The Journal of Clinical Psychiatry·Jenneke E WiersmaBrenda W J H Penninx
Aug 8, 2009·Biological Psychiatry·Patrick M BauerSeth D Pollak
Jul 10, 2010·Journal of Neurogenetics·Erika PedrosaHerbert M Lachman
Jul 16, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Tania L Roth, J David Sweatt
Sep 21, 2010·Nature Biotechnology·Christoph BockAlexander Meissner
Oct 1, 2010·Developmental Psychobiology·Christine HeimCharles B Nemeroff
Oct 12, 2010·Schizophrenia Bulletin·Irwin Feinberg
Nov 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Ronald C KesslerDavid R Williams
Nov 10, 2010·Archives of Neurology·Irfan A Qureshi, Mark F Mehler
Nov 26, 2010·Psychopharmacology·Gregory V Carr, Irwin Lucki
Jan 27, 2011·PloS One·Fabienne BrenetJoseph M Scandura
Feb 25, 2011·The Journal of Nervous and Mental Disease·María-José AlvarezFrancesc-Xavier Arrufat

❮ Previous
Next ❯

Citations

Nov 11, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Janusz K Rybakowski
Dec 8, 2020·The International Journal of Neuropsychopharmacology·Błażej MisiakPaweł Karpiński
May 11, 2021·Frontiers in Behavioral Neuroscience·Rebecca R Westwick, Clare C Rittschof
Aug 4, 2021·Nature Reviews. Neurology·Velda X HanRussell C Dale
Jan 7, 2022·Archives of Women's Mental Health·Sarah Kittel-SchneiderPatricia Trautmann-Villalba

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.