Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space

Seminars in Immunology
Nina SchmolkaBruno Silva-Santos

Abstract

γδ T cells are major providers of the pro-inflammatory cytokines interferon-γ (IFNγ) and interleukin-17 (IL-17) in protective or pathogenic immune responses. Notably, murine γδ T cells commit to either IFNγ or IL-17 production during development in the thymus, before any subsequent activation in the periphery. Here we discuss the molecular networks that underlie thymic γδ T cell differentiation, as well as the mechanisms that sustain or modify their functional properties in the periphery. We concentrate on recent findings on lymphoid and tissue-resident γδ T cell subpopulations, with an emphasis on genome-wide studies and their added value to elucidate the regulation of γδ T cell differentiation at the transcriptional and epigenetic (chromatin) levels.

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Citations

Apr 5, 2016·Nature Immunology·Miguel Muñoz-RuizBruno Silva-Santos
May 1, 2015·Seminars in Immunology·Joachim L Schultze
May 19, 2017·Nature Immunology·Pedro H PapottoBruno Silva-Santos
Dec 29, 2017·The Journal of Experimental Medicine·Guodong SunZhinan Yin
Aug 23, 2018·Immunology·Aoi Akitsu, Yoichiro Iwakura
Aug 18, 2020·Cellular and Molecular Life Sciences : CMLS·Yingping XuQing-Sheng Mi
Feb 25, 2017·Frontiers in Immunology·Camille KhairallahMyriam Capone
Jul 16, 2016·European Journal of Immunology·Terkild B BuusJens Peter H Lauritsen
Jul 21, 2017·Biomolecular Concepts·George AndersonRussel J Reiter
Jul 23, 2019·The Journal of Clinical Investigation·Katarzyna PlacekAnna C Aschenbrenner
Aug 6, 2019·Frontiers in Immunology·Konstantinos MengrelisTessa Crompton
Mar 30, 2017·Cancer Immunology Research·Elena Lo PrestiFrancesco Dieli
Oct 13, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yi-En YaoTian-Xia Huang

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