Epigenetic changes in mesenchymal stem cells differentiation

European Journal of Medical Genetics
Ibrahim Mortada, Rola Mortada

Abstract

Epigenetic factors are known to play a major role in determining stem cell fate and differentiation. Mesenchymal stem cells are the most studied population of stem cells due to their important applications in experimental biology and regenerative medicine. After a brief overview on mesenchymal stem cells, this review aims to highlight the role of epigenetic changes on mesenchymal stem cells biology and differentiation protocols with a focus on osteocytic, chondrocytic and adipocytic differentiation. Chromatin remodeling, DNA methylation, histone modifications and miRNA expression will be investigated. The impact of epigenetics on transdifferentiation of mesenchymal stem cells will also be discussed. Indeed, epigenetic modulation appears to constitute a promising experimental target in stem cell basic and translational research.

Citations

Jun 5, 2019·International Journal of Molecular Sciences·Fabio CofanoDiego Garbossa
Sep 11, 2019·Journal of Clinical Medicine·Armita Mahdavi GorabiAmirhossein Sahebkar
Dec 24, 2019·Journal of Cellular Physiology·Christopher R ParadiseAmel Dudakovic
May 8, 2020·International Journal of Molecular Sciences·Francesca DiomedeOriana Trubiani
Jul 28, 2019·Journal of Tissue Engineering and Regenerative Medicine·Cristina ManferdiniGina Lisignoli
Jan 11, 2019·Stem Cells International·Daniela Di TizioIvana Antonucci
Feb 7, 2020·Cell & Bioscience·Jianhan RenChen Zhou
Nov 3, 2020·Journal of Cellular Biochemistry·Rodrigo AguilarMartin Montecino
Feb 4, 2021·Regenerative Medicine·Mohammed A BananiFarshid Sefat
Oct 30, 2020·Stem Cell Research & Therapy·Mahsa GhorbaninejadMohamadreza Baghaban Eslaminejad
Nov 6, 2020·Stem Cells International·Dan ZhouWei Du
Mar 7, 2021·International Journal of Molecular Sciences·Chiara MazziottaFernanda Martini
Mar 23, 2021·DNA and Cell Biology·Rahyza I F AssisDenise C Andia
May 15, 2021·Bulletin du cancer·Sarah Watson

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