Epigenetic clock analysis of blood samples from Japanese schizophrenia patients

NPJ Schizophrenia
Satoshi OkazakiAkitoyo Hishimoto

Abstract

The accelerated aging hypothesis of schizophrenia (SCZ) has been proposed. DNA methylation profiles were developed for determining "epigenetic age." Here, we assessed intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA, respectively) in SCZ. We examined two independent cohorts of Japanese ancestry. The first cohort consisted of 80 patients with SCZ under long-term or repeated hospitalization and 40 controls, with the economical DNA pooling technique. The second cohort consisted of 24 medication-free patients with SCZ and 23 controls. Blood of SCZ subjects exhibited decreased EEAA in the first cohort (p = 0.0162), but not in the second cohort. IEAA did not differ in either cohort. We performed replication analyses using publicly available datasets from European ancestry (three blood and one brain datasets). One blood dataset showed increased EEAA in SCZ (p = 0.0228). Overall, our results provide evidence for decreased EEAA in SCZ associated with hospitalization in the Japanese population.

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Citations

May 31, 2019·Current Opinion in Psychiatry·Francesco S BersaniOwen M Wolkowitz
Aug 30, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Audrey LuoFalk W Lohoff
Dec 4, 2020·Schizophrenia Bulletin·Xiaohui WuCunyou Zhao
Nov 11, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Satoshi OkazakiAkitoyo Hishimoto
Jan 15, 2021·Psychiatry Research·Oluwagbenga DadaVincenzo De Luca
Dec 10, 2020·Alcoholism, Clinical and Experimental Research·Satoshi OkazakiAkitoyo Hishimoto
Mar 9, 2021·Ageing Research Reviews·Rezvan NorooziEwelina Pośpiech
Jul 17, 2021·Psychoneuroendocrinology·Fernanda TalaricoSintia I Belangero
Jul 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Seong Hoon Jeong, Yong Sik Kim

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Datasets Mentioned

BETA
GSE84727
GSE41169
GSE80417
GSE38873

Methods Mentioned

BETA
blood draw

Software Mentioned

EZR
R
AgeAccel
Power

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