Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties

International Journal of Cell Biology
Vincenzo GiancottiClaudio Rizzi

Abstract

High-mobility group A (HMGA) proteins have been examined to understand their participation as structural epigenetic chromatin factors that confer stem-like properties to embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs). The function of HMGA was evaluated in conjunction with that of other epigenetic factors such as histones and microRNAs (miRs), taking into consideration the posttranscriptional modifications (PTMs) of histones (acetylation and methylation) and DNA methylation. HMGA proteins were coordinated or associated with histone and DNA modification and the expression of the factors related to pluripotency. CSCs showed remarkable differences compared with ESCs and iPSCs.

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Citations

Jan 23, 2020·International Journal of Molecular Sciences·Robert Vignali, Silvia Marracci
Mar 17, 2020·Expert Opinion on Therapeutic Targets·Behzad MansooriBehzad Baradaran
Dec 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sayan ChakrabortyAmitava Sengupta

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Methods Mentioned

BETA
histone acetylation
acetylation
acetylates

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