Epigenetic Control of Circadian Clock Operation during Development.

Genetics Research International
Chengwei LiXiaodong Li

Abstract

The molecular players of circadian clock oscillation have been identified and extensively characterized. The epigenetic mechanisms behind the circadian gene expression control has also been recently studied, although there are still details to be illucidated. In this review, we briefly summarize the current understanding of the mammalian clock. We also provide evidence for the lack of circadian oscillation in particular cell types. As the circadian clock has intimate interaction with the various cellular functions in different type of cells, it must have plasticity and specicity in its operation within different epigenetic environments. The lack of circadian oscillation in certain cells provide an unique opportunity to study the required epigenetic environment in the cell that permit circadian oscillation and to idenfify key influencing factors for proper clock function. How epigenetic mechansims, including DNA methylaiton and chromatin modifications, participate in control of clock oscillation still awaits future studies at the genomic scale.

References

Apr 1, 1989·Brain Research. Developmental Brain Research·D R Weaver, S M Reppert
Apr 1, 1988·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·F C Davis, R A Gorski
Sep 2, 1988·Science·M R Ralph, M Menaker
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·F K Stephan, I Zucker
Jul 1, 1969·The Biochemical Journal·H Philippidis, F J Ballard
May 15, 1983·Experientia·H J BöhmeE Hofmann
May 27, 1983·Science·S M Reppert, W J Schwartz
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·L MontoliuG Schütz
Jan 1, 1993·Annual Review of Physiology·C S Pittendrigh
May 16, 1997·Cell·D P KingJ S Takahashi
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·J B HogeneschC A Bradfield
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·H SassiT Grange
Jan 19, 2000·Nature·B D Strahl, C D Allis
May 12, 2000·Science·L P ShearmanS M Reppert
Dec 2, 2000·Nature Neuroscience·C CrosioP Sassone-Corsi
Apr 11, 2001·The EMBO Journal·H ThomassinT Grange
Aug 11, 2001·Science·T Jenuwein, C D Allis
Aug 11, 2001·Science·W ReikJ Walter
Apr 23, 2002·Nature·Kai-Florian StorchCharles J Weitz
May 23, 2002·Cell·Satchidananda PandaJohn B Hogenesch
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Zdenka Travnickova-BendovaPaolo Sassone-Corsi
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Molecular Cell Biology
Eric E Zhang, Steve A Kay
Molecular and Cellular Endocrinology
Isabelle SchmutzJürgen A Ripperger
Handbook of Experimental Pharmacology
Ethan D Buhr, Joseph S Takahashi
© 2021 Meta ULC. All rights reserved