Epigenetic control of exercise adaptations in the equine athlete: Current evidence and future directions.

Equine Veterinary Journal
Joshua DenhamAllan J Davie

Abstract

Horses (Equus ferus caballus) have evolved over the past 300 years in response to man-made selection for particular athletic traits. Some of the selected traits were selected based on the size and horses' muscular power (eg Clydesdales), whereas other breeds were bred for peak running performance (eg Thoroughbred and Arabian). Although the physiological changes and some of the cellular adaptations responsible for athletic potential of horses have been identified, the molecular mechanisms are only just beginning to be comprehensively investigated. The purpose of this review was to outline and discuss the current understanding of the molecular mechanisms underpinning the athletic performance and cardiorespiratory fitness in athletic breeds of horses. A brief review of the biology of epigenetics is provided, including discussion on DNA methylation, histone modifications and small RNAs, followed by a summary and critical review of the current work on the exercise-induced epigenetic and transcriptional changes in horses. Important unanswered questions and currently unexplored areas that deserve attention are highlighted. Finally, a rationale for the analysis of epigenetic modifications in the context with exercise-related traits and...Continue Reading

References

Oct 24, 1991·Nature·S L LindstedtV Navarro
Oct 1, 1990·Australian Veterinary Journal·R J RoseP K Knight
Jan 1, 1989·Equine Veterinary Journal·B Essén-GustavssonJ Thornton
Feb 1, 1993·Australian Veterinary Journal·D E AuerA A Seawright
Jun 30, 1998·Pflügers Archiv : European journal of physiology·C M TylerR J Rose
Aug 22, 2000·Journal of Muscle Research and Cell Motility·A L Serrano, J L Rivero
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S J Wickler, T P Anderson
Feb 24, 2001·Pflügers Archiv : European journal of physiology·A L SerranoJ L Rivero
Dec 12, 2001·Acta Physiologica Scandinavica·C J GoreM J McKenna
Oct 31, 2002·Equine Veterinary Journal. Supplement·A R PösöE Pirilä
Dec 20, 2003·Cellular and Molecular Life Sciences : CMLS·J C Chow, C J Brown
Jan 24, 2004·Acta Physiologica Scandinavica·M WittwerM Flück
Mar 3, 2004·European Journal of Applied Physiology·Keisho KatayamaMiharu Miyamura
Feb 3, 2005·American Journal of Physiology. Endocrinology and Metabolism·Margarita Teran-GarciaClaude Bouchard
Feb 12, 2005·Journal of Applied Physiology·Michael S DavisKatherine K Williamson
Apr 13, 2005·American Journal of Veterinary Research·Eduard Jose-CunillerasKenneth W Hinchcliff
Apr 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James A TimmonsCarl Johan Sundberg
Jun 1, 2005·Research in Veterinary Science·K CappelliM Silvestrelli
Dec 1, 2005·Journal of Cell Science·Sabine M GörischKarsten Rippe
Nov 14, 2006·Research in Veterinary Science·Katia CappelliMaurizio Silvestrelli
Jul 10, 2007·Veterinary Immunology and Immunopathology·Douglas C DonovanDavid J Hurley
Aug 21, 2007·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Shuqing XuXiaoguang Zheng
Mar 28, 2008·RNA·Anja M DuursmaReuven Agami
Sep 9, 2008·Scandinavian Journal of Medicine & Science in Sports·B Friedmann-Bette
Sep 9, 2008·Scandinavian Journal of Medicine & Science in Sports·H HoppelerM Vogt
Feb 11, 2009·Medicine and Science in Sports and Exercise·Nigel K SteptoJohn A Hawley
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Carsten LundbyPaul Robach
Oct 29, 2009·Physiological Genomics·Suzanne S EiversEmmeline W Hill
Nov 3, 2009·Experimental Physiology·Scott K PowersErin E Talbert

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