Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages

Oncotarget
Amber E de Groot, Kenneth J Pienta

Abstract

The progression of cancer is a result of not only the growth of the malignant cells but also the behavior of other components of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are key components of the TME that influence tumor growth and disease progression. TAMs can either inhibit or support tumor growth depending on their polarization to classically-activated macrophages (M1s) or alternatively-activated macrophages (M2s), respectively. Epigenetic regulation plays a significant role in determining this polarization and manipulating the epigenetic regulation in macrophages would provide a means for selectively targeting M2s thereby eliminating tumor-supporting TAMs while sparing tumor-inhibiting M1 TAMs. Many pharmacologic modulators of epigenetic enzymes are currently used clinically and could be repurposed for treating tumors with high TAM infiltrate. While much research involving epigenetic enzymes and their modulators has been performed in M1s, significantly less is known about the epigenetic regulation of M2s. This review highlights the field's current knowledge of key epigenetic enzymes and their pharmacologic modulators known to influence macrophage polarization.

References

Jun 1, 2007·Nature·Simmie L FosterRuslan Medzhitov
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ainhoa Iglesias AraShelly C Lu
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos SebastiánAntonio Celada
Nov 18, 2008·Nature Immunology·Alejandro VillagraEduardo M Sotomayor
Dec 2, 2008·Journal of Molecular and Cellular Cardiology·Xiaocen KongYong Xu
Mar 21, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zheng ShenMin You
Dec 10, 2009·American Journal of Physiology. Endocrinology and Metabolism·Takeshi YoshizakiJerrold M Olefsky
Oct 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Di FengBetsy J Barnes
Nov 12, 2010·Nature·Edwige NicodemeAlexander Tarakhovsky
Mar 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hongwei WangEduardo M Sotomayor
Dec 14, 2011·Genes & Development·Shannon E MullicanMitchell A Lazar
Jan 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shyh-Kuan TaiShie-Liang Hsieh
Mar 24, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel F Camacho, Kenneth J Pienta
May 29, 2012·Molecular Cell·Yina ZhuSimona Saccani
Jul 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xuefen ChenGioacchino Natoli
Sep 22, 2012·Immunobiology·H L EamesI A Udalova
Dec 12, 2012·Trends in Immunology·Lionel B Ivashkiv
Dec 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jarrod PredinaSunil Singhal
Feb 20, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna C BelkinaGerald V Denis
Apr 2, 2013·International Immunopharmacology·Santosh VishwakarmaShridhar Narayanan

❮ Previous
Next ❯

Citations

Apr 2, 2019·Expert Opinion on Biological Therapy·Youngwoo ChoMansoor M Amiji
Aug 21, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alessandro VenosaDebra L Laskin
Sep 25, 2019·Nature Reviews. Clinical Oncology·Michael J TopperStephen B Baylin
May 13, 2020·Epigenomics·Jesús Beltrán-GarcíaJosé Luis García-Giménez
Feb 9, 2020·Intensive Care Medicine Experimental·Xiaoyan WenJohn A Kellum
Jul 6, 2020·Human Molecular Genetics·Jessica A CastrillonFeixiong Cheng
Nov 1, 2018·Journal of Cellular Physiology·Masoud NajafiKeywan Mortezaee
Oct 7, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·C RubioM Dueñas
Aug 21, 2019·Cancers·Rakesh KumarM Radhakrishna Pillai
Jan 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali VuralJohn H Kehrl
Jun 7, 2019·Hepatology Communications·Adrien Guillot, Frank Tacke
Nov 5, 2019·Frontiers in Cellular Neuroscience·Tatyana VeremeykoEugene D Ponomarev
Dec 18, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Austin BoucherRichard Dahl
Dec 18, 2020·Frontiers in Immunology·Yangzhi QiQianxue Chen
Mar 26, 2021·Clinical Epigenetics·Iris LodewijkJesús M Paramio
Mar 26, 2021·Frontiers in Immunology·Sajjad MuhammadDaniel Hänggi
Apr 2, 2021·Frontiers in Oncology·Fang WangWei Qiu
Jun 3, 2021·Journal of Clinical Medicine·Gaetano GalloGiuseppe Sammarco
Jun 3, 2021·Cells·Gabriela Rapozo GuimarãesMariana Boroni
Jun 8, 2021·Frontiers in Immunology·Kewei LiuKe Jiang
Jun 29, 2021·Seminars in Cancer Biology·Diego M Avella PatinoJonathan B Mitchem
Jul 28, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Kalyani KarnamOnkar Prakash Kulkarni

❮ Previous
Next ❯

Methods Mentioned

BETA
histone acetylation
acetylation

Related Concepts

Related Feeds

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Related Papers

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
W HuC Wu
International Journal of Molecular Sciences
Karin Binnemars-PostmaJai Prakash
© 2022 Meta ULC. All rights reserved