PMID: 2111735Jun 1, 1990Paper

Epigenetic control of transgene expression and imprinting by genotype-specific modifiers

Cell
N D AllenM A Surani

Abstract

Expression and DNA methylation of the transgene locus TKZ751 are controlled by genotype-specific modifier genes. The DBA/2 and 129 genetic backgrounds enhanced expression, while the BALB/c background suppressed expression, but only following maternal inheritance of the BALB/c modifier. Epigenetic modification of the transgene locus was cumulative over successive generations, which in BALB/c mice resulted in an irreversible methylation after three consecutive germline passages. Therefore, at the TKZ751 locus the germline fails to reverse previously acquired epigenetic modifications, a process that is usually essential to restore the genomic totipotency. Hence the genotype-specific modifier genes regulate penetrance and expressivity as well as parental imprinting of the TKZ751 locus through epigenetic modification.

References

Jan 30, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M A SuraniW Reik
Jan 1, 1989·Progress in Nucleic Acid Research and Molecular Biology·C SapienzaA Peterson
Jan 1, 1989·Annals of the New York Academy of Sciences·C Sapienza
Oct 1, 1989·Trends in Genetics : TIG·W Reik
Aug 1, 1988·Genes & Development·M Monk
Jan 1, 1988·Annual Review of Genetics·D Solter
Mar 1, 1988·Trends in Genetics : TIG·M A SuraniN D Allen
Oct 9, 1987·Science·R Holliday
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D C Kaslow, B R Migeon
Apr 1, 1958·The Journal of Experimental Zoology·K P HUMMEL

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Citations

Sep 14, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D W Zeh, J A Zeh
Oct 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·I S ThoreyR G Oshima
Aug 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A S Wilkins
Mar 1, 1994·Molecular Reproduction and Development·A J Villar, R A Pedersen
Jun 1, 1995·Diabetologia·C PolychronakosE Colle
Mar 1, 1993·Behavior Genetics·M J Durcan, D Goldman
Feb 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·J W Gordon, M W Bradbury
May 1, 1994·Transgenic Research·C CuiP J Stambrook
Jul 30, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Daniel K Morgan, Emma Whitelaw
Jan 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K Schuster-GosslerA Gossler
Nov 19, 2009·Journal of Biosciences·Simona Ginsburg, Eva Jablonka
Jun 1, 1994·Mutation Research·J R Chaillet
Apr 16, 1991·Biochimica Et Biophysica Acta·C Sapienza
Feb 1, 1993·Hearing Research·L C ErwayD E Harrison
Jun 1, 1992·Current Opinion in Cell Biology·L Pillus
Feb 28, 2001·Trends in Genetics : TIG·A Petronis
Jul 20, 2002·Trends in Genetics : TIG·Vardhman K RakyanEmma Whitelaw
Jan 4, 2001·Reproductive Toxicology·S L Beck
Aug 1, 1991·Current Opinion in Genetics & Development·M A Surani
May 5, 2001·The Biochemical Journal·V K RakyanE Whitelaw
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K A RothJ I Gordon
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K Salehi-AshtianiE Goldberg
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·K W DobieM McClenaghan
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·K PfeiferS M Tilghman
Aug 10, 1996·AIDS Research and Human Retroviruses·P DickieL J Chang

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