Epigenetic deregulation of the COX pathway in cancer

Progress in Lipid Research
Inês Cebola, Miguel A Peinado

Abstract

Inflammation is a major cause of cancer and may condition its progression. The deregulation of the cyclooxygenase (COX) pathway is implicated in several pathophysiological processes, including inflammation and cancer. Although, its targeting with nonsteroidal antiinflammatory drugs (NSAIDs) and COX-2 selective inhibitors has been investigated for years with promising results at both preventive and therapeutic levels, undesirable side effects and the limited understanding of the regulation and functionalities of the COX pathway compromise a more extensive application of these drugs. Epigenetics is bringing additional levels of complexity to the understanding of basic biological and pathological processes. The deregulation of signaling and biosynthetic pathways by epigenetic mechanisms may account for new molecular targets in cancer therapeutics. Genes of the COX pathway are seldom mutated in neoplastic cells, but a large proportion of them show aberrant expression in different types of cancer. A growing body of evidence indicates that epigenetic alterations play a critical role in the deregulation of the genes of the COX pathway. This review summarizes the current knowledge on the contribution of epigenetic processes to the dere...Continue Reading

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Feb 4, 2014·Expert Opinion on Drug Discovery·Mohsen Vosooghi, Mohsen Amini
Mar 29, 2014·Expert Opinion on Investigational Drugs·Wesley R Samore, Christopher S Gondi
May 6, 2015·The Biochemical Journal·Edna Zhi Pei ChaiGautam Sethi
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Jul 24, 2014·Molecular and Clinical Oncology·Hiroshi YokouchiMasaharu Nishimura
Jul 1, 2016·Signal Transduction and Targeted Therapy·Qingxiang SunDa Jia
Jun 12, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xue-Yin PanJun Li

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