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Epigenetic drugs that do not target enzyme activity

Drug Discovery Today. Technologies

Jul 17, 2014

Dafydd R Owen, John D Trzupek

Abstract

While the installation and removal of epigenetic post-translational modifications or ‘marks’ on both DNA and histone proteins are the tangible outcome of enzymatically catalyzed processes, the role of the epigenetic reader proteins looks, at first, less obvious. As they do not catalyze ...read more

Mentioned in this Paper

Histone antigen
Post-Translational Protein Processing
Transcription, Genetic
Gene Deletion Abnormality
DNA Methylation
Plasma Protein Binding Capacity
DNA Modification Methylases
Study of Epigenetics
Enzyme Activity
Deletion Mutation
2
40
Paper Details
References
  • References27
  • Citations2
123
  • References27
  • Citations2

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Epigenetic drugs that do not target enzyme activity

Drug Discovery Today. Technologies

Jul 17, 2014

Dafydd R Owen, John D Trzupek

PMID: 25027371

DOI: 10.1016/j.ddtec.2012.10.008

Abstract

While the installation and removal of epigenetic post-translational modifications or ‘marks’ on both DNA and histone proteins are the tangible outcome of enzymatically catalyzed processes, the role of the epigenetic reader proteins looks, at first, less obvious. As they do not catalyze ...read more

Mentioned in this Paper

Histone antigen
Post-Translational Protein Processing
Transcription, Genetic
Gene Deletion Abnormality
DNA Methylation
Plasma Protein Binding Capacity
DNA Modification Methylases
Study of Epigenetics
Enzyme Activity
Deletion Mutation
2
40

Similar Papers Found In These Feeds

Histone Acetyltransferases (Keystone)

Histone acetyltransferases are important chromatin modifying enzymes that catalyze acetylation of specific lysine residues in histone and nonhistone substrates to regulate gene expression. Here is the latest research.


Histone Deacetylases (Keystone)

Histone deacetylases (HDACs) are a class of chromatin-modifying enzymes that remove specific acetyl groups from histones, allowing the histones to wrap DNA more tightly, thus leading to alterations in gene expression. Here is the latest research on HDACs including SIRT6.

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Angewandte Chemie

Graphical Abstract

Angewandte ChemieOctober 10, 2001
Günther WessBirgitt Sickenberger
Angewandte Chemie

Graphical Abstract

Angewandte ChemieOctober 10, 2001
Les P. Miranda, Morten Meldal
Paper Details
References
  • References27
  • Citations2
123
  • References27
  • Citations2
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