Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress

Oxidative Medicine and Cellular Longevity
Fiona LimanaqiF Fornai

Abstract

Methamphetamine is a widely abused drug, which possesses neurotoxic activity and powerful addictive effects. Understanding methamphetamine toxicity is key beyond the field of drug abuse since it allows getting an insight into the molecular mechanisms which operate in a variety of neuropsychiatric disorders. In fact, key alterations produced by methamphetamine involve dopamine neurotransmission in a way, which is reminiscent of spontaneous neurodegeneration and psychiatric schizophrenia. Thus, understanding the molecular mechanisms operated by methamphetamine represents a wide window to understand both the addicted brain and a variety of neuropsychiatric disorders. This overlapping, which is already present when looking at the molecular and cellular events promoted immediately after methamphetamine intake, becomes impressive when plastic changes induced in the brain of methamphetamine-addicted patients are considered. Thus, the present manuscript is an attempt to encompass all the molecular events starting at the presynaptic dopamine terminals to reach the nucleus of postsynaptic neurons to explain how specific neurotransmitters and signaling cascades produce persistent genetic modifications, which shift neuronal phenotype and i...Continue Reading

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Citations

May 8, 2019·International Journal of Molecular Sciences·Fiona LimanaqiFrancesco Fornai
Mar 4, 2020·International Journal of Molecular Sciences·Fiona LimanaqiFrancesco Fornai
Jul 10, 2020·Journal of Dual Diagnosis·John R RichardsSamuel D Turnipseed
May 18, 2019·Journal of Neurochemistry·Shanshan LuJie Yan
Jul 7, 2019·International Journal of Molecular Sciences·Fiona LimanaqiFrancesco Fornai
Sep 7, 2018·Frontiers in Molecular Neuroscience·Fiona LimanaqiFrancesco Fornai
Aug 1, 2018·International Journal of Molecular Sciences·Larisa RyskalinFrancesco Fornai
Jan 27, 2021·Neuroscience and Biobehavioral Reviews·Francesco Fornai, Stefano Puglisi-Allegra
Oct 24, 2020·Frontiers in Psychiatry·Fiona LimanaqiStefano Puglisi-Allegra
May 17, 2019·Neuroscience and Biobehavioral Reviews·Fiona LimanaqiFrancesco Fornai
Jun 2, 2021·European Journal of Histochemistry : EJH·Fiona LimanaqiFrancesco Fornai

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Methods Mentioned

BETA
deamination
acetylation
Histone Acetylation

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