Epigenetic effects of shiftwork on blood DNA methylation.

Chronobiology International
Valentina BollatiGiovanni Costa

Abstract

In the present study, the authors investigated the effects of shiftwork exposure on DNA methylation using peripheral blood DNA from subjects working in two chemical plants in Northern Italy. The investigation was designed to evaluate (a) DNA methylation changes in Alu and long interspersed nuclear element-1 (LINE-1) repetitive elements as a surrogate of global methylation and (b) promoter methylation of glucocorticoid receptor (GCR), tumor necrosis factor alpha (TNF-alpha), and interferon-gamma (IFN-gamma). One hundred and fifty white male workers (mean +/- SD: 41.0 +/- 9 yrs of age) were examined: 100 3 x 8 rotating shiftworkers (40.4 +/- 8.7 yrs of age) and 50 day workers (42.2 +/- 9.4 yrs of age). The authors used bisulfite-pyrosequencing to estimate repetitive elements and gene-specific methylation. Multiple regression analysis, adjusted for age, body mass index (BMI), and job seniority, did not show any significant association between the five DNA methylation markers and shiftwork. However, job seniority, in all subjects, was significantly associated with Alu (beta = -0.019, p = .033) and IFN-gamma (beta = -0.224, p < .001) methylation, whereas TNF-alpha methylation was inversely correlated with age (beta = -0.093, p < .00...Continue Reading

References

Jan 1, 1990·Annals of the New York Academy of Sciences·K J Tracey, A Cerami
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Mar 15, 2003·Occupational Medicine·Anders Knutsson
Feb 20, 2004·Nucleic Acids Research·Allen S YangJean-Pierre J Issa
Aug 18, 2004·Sleep Medicine Reviews·T Akerstedt
Mar 26, 2005·Carcinogenesis·Shou-Tung ChenJan-Gowth Chang
Jul 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Wendy DeanFátima Santos
Dec 6, 2005·Nucleic Acids Research·Daniel J WeisenbergerPeter W Laird
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yong ZhuPeter Boyle
Apr 6, 2006·Cancer Causes & Control : CCC·Erhard Haus, Michael Smolensky
Feb 7, 2007·Cancer Research·Valentina BollatiAllen S Yang
Apr 4, 2007·The Journal of Clinical Investigation·Jingwu Zhang
Apr 25, 2007·Chronobiology International·Dominikus BönschStefan Bleich
May 23, 2007·Molecular and Cellular Biology·K E SullivanM Bhatia
May 25, 2007·Nature·Andrew P Feinberg
May 31, 2007·Cell Cycle·Saurabh Sahar, Paolo Sassone-Corsi
Jul 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gionata CavadiniAdriano Fontana
Sep 26, 2007·International Journal of Cancer. Journal International Du Cancer·S Perwez Hussain, Curtis C Harris
Nov 6, 2007·Advances in Immunology·Jamie R Schoenborn, Christopher B Wilson
Dec 14, 2007·Chronobiology International·Erhard Haus
Jan 16, 2008·Die Naturwissenschaften·Thomas C ErrenClaus Piekarski
May 20, 2008·Chronobiology International·Nicoletta BiggiGiovanni Costa
Jul 16, 2008·Chronobiology International·Alain Reinberg, Israel Ashkenazi
Nov 14, 2008·Chronobiology International·Francesco PortaluppiMichael H Smolensky
Dec 6, 2008·Environmental Health Perspectives·Jennifer A RusieckiEva C Bonefeld-Jorgensen
Jan 13, 2009·American Journal of Respiratory and Critical Care Medicine·Andrea BaccarelliJoel Schwartz
Jan 15, 2009·Chronobiology International·Itai KloogBoris A Portnov
Jan 20, 2009·Mechanisms of Ageing and Development·Valentina BollatiAndrea Baccarelli
Mar 10, 2009·Environmental Health Perspectives·Letizia TarantiniAndrea Baccarelli
Dec 1, 2007·The Lancet Oncology·Kurt StraifUNKNOWN WHO International Agency For Research on Cancer Monograph Working Group
Apr 11, 2009·Chronobiology International·Yolande EsquirolBertrand Perret
Apr 22, 2009·International Journal of Epidemiology·Richard G Stevens
Jul 29, 2009·Chronobiology International·Yasushi SuwazonoKouichi Sakata
Aug 11, 2009·Current Opinion in Pediatrics·Andrea Baccarelli, Valentina Bollati
Sep 5, 2009·Chronobiology International·Thomas Kantermann, Till Roenneberg
Dec 25, 2009·Chronobiology International·David Duguay, Nicolas Cermakian
Jan 13, 2010·Environmental Health Perspectives·Robert O WrightAndrea Baccarelli

❮ Previous
Next ❯

Citations

Dec 18, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mukesh VermaJohn P A Ioannidis
Nov 30, 2011·Epigenomics·Jorge Alejandro Alegría-TorresValentina Bollati
Mar 20, 2014·Annual Review of Public Health·Laura S RozekGilbert S Omenn
Jan 31, 2014·Current Neurology and Neuroscience Reports·Irfan A Qureshi, Mark F Mehler
Sep 5, 2014·Chronobiology International·Parveen BhattiPei Wang
Jan 24, 2016·Environmental and Molecular Mutagenesis·Claudia ConsalesMarcello Spanò
Nov 30, 2012·Environmental and Molecular Mutagenesis·Daniel I JacobsYong Zhu
Jun 4, 2014·Environmental and Molecular Mutagenesis·Giorgio LeterMarcello Spanò
Jul 24, 2014·Immunology·Nicola L D Smith, David W Denning
Sep 5, 2015·BioMed Research International·Francesca Pacchierotti, Marcello Spanò
Feb 14, 2012·Chronobiology International·Marie DumontJean Paquet
Mar 22, 2015·Sleep Medicine·Pan WangZe-Fang Ren
Jul 10, 2012·Molecular Aspects of Medicine·F I MilagroJ A Martínez
Oct 25, 2016·International Journal of Colorectal Disease·M AlexanderJ R Hébert
Nov 9, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ilona SchneiderChrista Hohoff
Mar 18, 2019·International Journal of Epidemiology·Alexandra J WhiteJack A Taylor
Mar 27, 2019·PloS One·Jin ZhouJefferey L Burgess
Nov 17, 2017·Chronobiology International·Edyta ReszkaBeata Pepłońska
Nov 17, 2017·Chronobiology International·Agnieszka Bukowska-DamskaBeata Peplonska
Jul 3, 2019·International Journal of Environmental Research and Public Health·Michele CarugnoAngela Cecilia Pesatori
Nov 7, 2017·Chronobiology International·Agnieszka Bukowska-DamskaBeata Peplonska
Jan 16, 2014·Advances in Nutrition·J Alfredo MartínezKevin L Schalinske

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.