Epigenetic heredity: RNA-mediated modes of phenotypic variation

Annals of the New York Academy of Sciences
Minoo Rassoulzadegan, François Cuzin

Abstract

In addition to the Mendelian mutations, several instances of heritable phenotypic variation have been reported. We have observed, in mice, a role for sperm RNAs in the induction of such stable phenotypic variation. When experimentally transferred by RNA microinjection into fertilized mouse eggs, the noncoding RNAs homologous in sequence to the target locus are efficient inducers of variation at the transcriptional level. Transmission of the phenotypic variation to progeny is highly efficient and independent of gender. Here, we have summarized these finding and how they relate to other reports of epigenetic variation.

References

Mar 30, 2001·Nature Genetics·E Whitelaw, D I Martin
Sep 2, 2005·Nature Reviews. Genetics·Stephen A Krawetz
Jan 5, 2006·European Journal of Human Genetics : EJHG·Marcus E PembreyUNKNOWN ALSPAC Study Team
May 26, 2006·Nature·Minoo RassoulzadeganFrançois Cuzin
Jul 21, 2006·Nature·Mary AllemanVicki L Chandler
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Noora Kotaja, Paolo Sassone-Corsi
Jun 10, 2008·Developmental Cell·Kay D WagnerMinoo Rassoulzadegan
Jun 16, 2009·Nature·Saher Sue HammoudBradley R Cairns
Oct 13, 2009·Development·Valérie GrandjeanMinoo Rassoulzadegan
Dec 1, 2009·Trends in Genetics : TIG·John S MattickGeoffrey J Faulkner
Sep 9, 2010·Essays in Biochemistry·François Cuzin, Minoo Rassoulzadegan
Feb 19, 2011·Frontiers in Behavioral Neuroscience·Isabelle C WeissIsabelle M Mansuy
Sep 18, 2012·PloS One·Mitsuoki KawanoMinoo Rassoulzadegan
Jan 26, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·M V E VeenendaalT J Roseboom
May 30, 2013·PLoS Genetics·Jafar KianiMinoo Rassoulzadegan
Apr 15, 2014·Nature Neuroscience·Katharina GappIsabelle M Mansuy
Jul 8, 2014·Developmental Cell·Benjamin R CaroneOliver J Rando

❮ Previous
Next ❯

Citations

Jul 23, 2016·Mechanisms of Development·Malgorzata KlocSzczepan M Bilinski
Aug 2, 2016·Zoology : Analysis of Complex Systems, ZACS·Anne Beemelmanns, Olivia Roth
Mar 14, 2019·Annals of the New York Academy of Sciences·Luis P Villarreal, Guenther Witzany
Sep 30, 2017·Frontiers in Microbiology·Karin MoellingShinichi Sunagawa
Oct 16, 2020·International Journal of Molecular Sciences·Miriam RuoccoEmanuela Dattolo
May 17, 2021·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Na ZhaoBo Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Methods in Cell Biology
Melani S Cheers, Charles A Ettensohn
Revue médicale de Liège
P Dodinval
© 2022 Meta ULC. All rights reserved