PMID: 22333230Feb 16, 2012Paper

Epigenetic inactivation of SPOCK2 in the malignant transformation of ovarian endometriosis

Zhonghua fu chan ke za zhi
Fang RenTong Li

Abstract

To investigate epigenetic inactivation of SPOCK2 gene in the malignant transformation of ovarian endometriosis (EM) by comparing the methylation status and protein expression of SPOCK2 gene in the malignant tissues, ectopic endometria and the eutopic endometria of endometriosis. From Jan. 2005 to Jan. 2011, 22 paraffin-embedded specimens diagnosed as malignant transformation of ovarian endometriosis (EAOC) including 11 cases with ovarian endometrioid carcinoma, 8 cases with clear cell carcinoma, 2 cases with serous cystadenocarcinoma and 1 case with mucous cystoadenocarcinoma matched with 22 cases with ovarian endometriosis and 16 cases with normal endometrium form cervical intraepithelial neoplasia(CIN) patients as controls in Department of Obstetrics and Gynecology of Shengjing Hospital. Twenty-two malignant tissues, 15 ectopic endometria and 10 eutopic endometria were captured by microdissection in EAOC group; 22 ectopic endometria and 17 eutopic endometria were captured in EM group; 22 endometrium were captured in the NE group. The methylation statue of SPOCK2 was determined by combined bisulfite restriction analysis, and the protein expression of SPOCK2 was evaluated by immunohistochemistry. (1) Methylation of SPOCK2: in t...Continue Reading

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