Epigenetic inheritance and evolution: A paternal perspective on dietary influences

Progress in Biophysics and Molecular Biology
Adelheid Soubry

Abstract

The earliest indications for paternally induced transgenerational effects from the environment to future generations were based on a small number of long-term epidemiological studies and some empirical observations. Only recently have experimental animal models and a few analyses on human data explored the transgenerational nature of phenotypic changes observed in offspring. Changes include multiple metabolic disorders, cancer and other chronic diseases. These phenotypes cannot always be explained by Mendelian inheritance, DNA mutations or genetic damage. Hence, a new compelling theory on epigenetic inheritance is gaining interest, providing new concepts that extend Darwin's evolutionary theory. Epigenetic alterations or "epimutations" are being considered to explain transgenerational inheritance of parentally acquired traits. The responsible mechanisms for these epimutations include DNA methylation, histone modification, and RNA-mediated effects. This review explores the literature on a number of time-dependent environmentally induced epigenetic alterations, specifically those from dietary exposures. We suggest a role for the male germ line as one of nature's tools to capture messages from our continuously changing environment...Continue Reading

References

Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
May 1, 1974·British Journal of Preventive & Social Medicine·J Fabia, T D Thuy
Mar 1, 1984·Journal of Epidemiology and Community Health·J R Wilkins, T H Sinks
Apr 1, 1999·Journal of Hypertension·T J RoseboomO P Bleker
May 27, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Susan K Murphy, Randy L Jirtle
Mar 3, 2004·American Journal of Human Genetics·Emily L Niemitz, Andrew P Feinberg
Jan 5, 2006·European Journal of Human Genetics : EJHG·Marcus E PembreyUNKNOWN ALSPAC Study Team
Feb 28, 2006·Nutrition·Lucy M AndersonW Gregory Alvord
Mar 15, 2006·Nature Reviews. Genetics·Eric J Richards
Sep 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Igor KoturbashOlga Kovalchuk
Oct 14, 2006·American Journal of Human Biology : the Official Journal of the Human Biology Council·R C PainterT J Roseboom
Mar 17, 2007·Nature Reviews. Genetics·Randy L Jirtle, Michael K Skinner
Mar 4, 2008·Nature Structural & Molecular Biology·Lasse SinkkonenWitold Filipowicz
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan T HeijmansL H Lumey
Mar 28, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Alexander V Badyaev, Tobias Uller
Jul 2, 2009·Nutrition Reviews·Adam Drewnowski
Sep 18, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·David MillerDavid Iles
Oct 16, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Radhika DasRandy L Jirtle
Oct 31, 2009·Journal of Assisted Reproduction and Genetics·Ozlem Tunc, Kelton Tremellen
Nov 7, 2009·European Journal of Epidemiology·Anh Duc NgoChristine L Roberts
Jan 28, 2010·Gene·Rita RebolloCristina Vieira
Jul 24, 2010·International Journal of Andrology·H W BakosM Lane
Oct 26, 2010·Asian Journal of Andrology·Timothy G Jenkins, Douglas T Carrell
Dec 2, 2010·Human Fertility : Journal of the British Fertility Society·Marcus E Pembrey
Apr 21, 2011·Journal of Evolutionary Biology·N SheaT Uller
Aug 26, 2011·Cancer Causes & Control : CCC·Alison ReidLin Fritschi
Aug 30, 2011·Reproduction, Fertility, and Development·Nicole O PalmerMichelle Lane
Nov 4, 2011·Epigenetics : Official Journal of the DNA Methylation Society·C Joana MarquesMário Sousa
Nov 30, 2011·Epigenomics·Vicki R Nelson, Joseph H Nadeau
Apr 13, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Timothy G Jenkins, Douglas T Carrell
Sep 15, 2012·Progress in Biophysics and Molecular Biology·Eva Jablonka
Nov 21, 2012·Journal of Evolutionary Biology·R Bonduriansky, T Day
Dec 18, 2012·Human Reproduction Update·N SermondadeS Czernichow

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Citations

Oct 11, 2015·Fertility and Sterility·Timothy G JenkinsDouglas T Carrell
Mar 2, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Melvin M BonillaDavid W Zeh
Jul 9, 2016·Environmental Epigenetics·Mark A Hanson, Michael K Skinner
Mar 26, 2016·Pharmacology & Therapeutics·Yingmei Zhang, Jun Ren
May 6, 2015·Seminars in Cell & Developmental Biology·Rachel Stegemann, David A Buchner
May 10, 2016·Clinical Epigenetics·Adelheid SoubrySusan K Murphy
Sep 1, 2016·Nature Reviews. Urology·Undraga Schagdarsurengin, Klaus Steger
Apr 18, 2018·Journal of Developmental Origins of Health and Disease·P V CarapetoM B Aguila
Nov 11, 2017·Basic and Clinical Andrology·Georges RaadValérie Grandjean
Feb 2, 2018·Current Molecular Biology Reports·Sam HoufflynAdelheid Soubry
Jan 16, 2018·Epigenomics·Brandon L Pearson, Dan Ehninger
May 8, 2018·Environmental Epigenetics·Carlos Guerrero-BosagnaFrédérique Pitel
May 8, 2018·Environmental Epigenetics·Adelheid Soubry
Feb 24, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Pamela ScorzaUNKNOWN Program Collaborators for Environmental influences on Child Health Outcomes
Feb 12, 2019·PloS One·Georges RaadMira Hazzouri
Jan 23, 2019·Reproduction : the Official Journal of the Society for the Study of Fertility·Jonathan P EvansFrancisco Garcia-Gonzalez
Feb 23, 2018·Nature·George C PattonSusan M Sawyer
Jun 25, 2016·Scientific Reports·Camile Castilho FontellesSonia de Assis
May 14, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Michael K SkinnerJohn R McCarrey
Feb 1, 2015·Reproduction, Fertility, and Development·Robert John AitkenParviz Gharagozloo
Dec 19, 2015·Reproduction, Fertility, and Development·Serafín Pérez-CerezalesAlfonso Gutiérrez-Adán
Sep 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Farah BughioKeith A Maggert
Sep 6, 2019·Journal of Developmental Origins of Health and Disease·Amy R NicholsElizabeth M Widen
Apr 25, 2020·Andrologia·Kristian Leisegang, Sulagna Dutta
Nov 24, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Adelheid Soubry
May 5, 2016·Environmental Epigenetics·Kayla C AkkermanAlison G Scoville
Jul 1, 2018·Heredity·Simone Immler
Aug 31, 2018·Current Diabetes Reports·Véronique GingrasEmily Oken
Aug 9, 2020·Journal of Clinical Medicine·Matilde CesconRenata S Tavares
Feb 17, 2017·Biology Letters·Felix ZajitschekMollie Manier
Apr 13, 2018·Reproductive Sciences·Sharvari S Deshpande, Nafisa H Balasinor
Mar 2, 2018·Environmental Epigenetics·Adelheid SoubryHeather M Stapleton

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