Epigenetic landscape in PPARγ2 in the enhancement of adipogenesis of mouse osteoporotic bone marrow stromal cell

Biochimica Et Biophysica Acta
Yong-Xing ZhangQing-Hua Zhao

Abstract

Osteoporosis is one of the most prevalent skeletal system diseases; yet, its pathophysiological mechanisms remain elusive. Adipocytes accumulate remarkably in the bone marrow of osteoporotic patients. The potential processes and molecular mechanisms underlying adipogenesis in osteoporotic BMSCs have attracted significant attention as adipocytes and osteoblasts share common precursor cells. Some environmental factors influence bone mass through epigenetic mechanisms; however, the role of epigenetic modifications in osteoporosis is just beginning to be investigated, and there is still little data regarding their involvement. In the current study, we investigated how epigenetic modifications, including DNA methylation and histone modifications, lead to adipogenesis in the bone marrow during osteoporosis. A glucocorticoid-induced osteoporosis (GIO) mouse model was established, and BMSCs were isolated from the bone marrow. Compared with normal BMSCs, osteoporotic BMSCs had significantly increased adipogenesis potential and decreased osteogenesis potential. In osteoporotic BMSCs, PPARγ2 regulatory region DNA hypo-methylation, histone 3 and 4 hyper-acetylation and H3K9 hypo-di-methylation were observed. These epigenetic modifications ...Continue Reading

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Citations

Jul 6, 2018·European Journal of Endocrinology·Tareck Rharass, Stephanie Lucas
Nov 12, 2019·The Journal of International Medical Research·Yaoqing WangFan Chen
Aug 15, 2020·Current Osteoporosis Reports·Dimitrios Cakouros, Stan Gronthos
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Jan 31, 2019·International Journal of Molecular Sciences·Cheng TianQiong Xu
Mar 12, 2020·Apoptosis : an International Journal on Programmed Cell Death·Tiantian WangChengqi He
Apr 29, 2021·BMC Musculoskeletal Disorders·Wenting XuYoujia Xu
May 5, 2021·Cell Death Discovery·Kun LiZiqiang Wang
Jul 13, 2021·Journal of Bone and Mineral Metabolism·Yuexin XuDuan Ma
Aug 9, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhonghua XuHaoyu Yang

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