Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.

The Journal of Allergy and Clinical Immunology
Andréanne MorinCarole Ober

Abstract

The upper airways present a barrier to inhaled allergens and microbes, which alter immune responses and subsequent risk for diseases, such as allergic rhinitis (AR). We tested the hypothesis that early-life microbial exposures leave a lasting signature in DNA methylation that ultimately influences the development of AR in children. We studied upper airway microbiota at 1 week, 1 month, and 3 months of life, and measured DNA methylation and gene expression profiles in upper airway mucosal cells and assessed AR at age 6 years in children in the Copenhagen Prospective Studies on Asthma in Childhood birth cohort. We identified 956 AR-associated differentially methylated CpGs in upper airway mucosal cells at age 6 years, 792 of which formed 3 modules of correlated differentially methylated CpGs. The eigenvector of 1 module was correlated with the expression of genes enriched for lysosome and bacterial invasion of epithelial cell pathways. Early-life microbial diversity was lower at 1 week (richness P = .0079) in children with AR at age 6 years, and reduced diversity at 1 week was also correlated with the same module's eigenvector (ρ = -0.25; P = 3.3 × 10-5). We show that the effect of microbiota richness at 1 week on risk for AR at ...Continue Reading

Citations

Mar 7, 2021·Nutrients·Nathalie AcevedoBetty C A M van Esch
Feb 4, 2021·American Journal of Respiratory and Critical Care Medicine·Daniela RagoBo L Chawes
May 3, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Yu ZhangSong Shi
Jun 29, 2021·Current Opinion in Immunology·Donata Vercelli
Jul 10, 2021·Pediatric Research·Jennifer Bermick, Matthew Schaller
Aug 21, 2021·European Journal of Immunology·Julie DeckersErika von Mutius

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