Epigenetic markers in inflammation-related genes associated with mood disorder: a cross-sectional and longitudinal study in high-risk offspring of bipolar parents

International Journal of Bipolar Disorders
Anne DuffyGustavo Turecki

Abstract

Bipolar disorder is highly heritable and typically onsets in late adolescence or early adulthood. Evidence suggests that immune activation may be a mediating pathway between genetic predisposition and onset of mood disorders. Building on a prior study of mRNA and protein levels in high-risk offspring published in this Journal, we conducted a preliminary examination of methylation profiles in candidate immune genes from a subsample of well-characterized emergent adult (mean 20 years) offspring of bipolar parents from the Canadian Flourish high-risk cohort. Models were adjusted for variable age at DNA collection, sex and antidepressant and mood stabilizer use. On cross-sectional analysis, there was evidence of higher methylation rates for BDNF-1 in high-risk offspring affected (n = 27) and unaffected (n = 23) for mood disorder compared to controls (n = 24) and higher methylation rates in affected high-risk offspring for NR3C1 compared to controls. Longitudinal analyses (25 to 34 months) provided evidence of steeper decline in methylation rates in controls (n = 24) for NR3C1 compared to affected (n = 15) and unaffected (n = 11) high-risk offspring and for BDNF-2 compared to affected high-risk. There was insufficient evidence that ...Continue Reading

References

Feb 3, 2011·The American Journal of Psychiatry·Elliot S GershonChunyu Liu
Mar 13, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Thomas G SchulzeFrancis J McMahon
May 4, 2013·Brain, Behavior, and Immunity·Charles L Raison, Andrew H Miller
Nov 23, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Anne DuffyPaul Grof
Apr 27, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Magdalena WiędłochaAgata Szulc
May 4, 2018·Scientific Reports·Christiane ThedaJeffrey M Craig
Aug 4, 2018·Progress in Molecular Biology and Translational Science·Laura M FioriGustavo Turecki

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Citations

Feb 13, 2020·International Journal of Bipolar Disorders·Ashley L ComesUrs Heilbronner
Apr 9, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Giselli ScainiJoao Quevedo
Oct 9, 2020·Bipolar Disorders·Sorcha BoltonKate E A Saunders
Aug 30, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·M MaziadeA M Gagné

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Methods Mentioned

BETA
amplicon sequencing

Software Mentioned

SAS

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