Aug 2, 2020

Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden

Clinical Epigenetics
Robert F. HillaryRiccardo E. Marioni

Abstract

Individuals of the same chronological age display different rates of biological ageing. A number of measures of biological age have been proposed which harness age-related changes in DNA methylation profiles. These measures include five 'epigenetic clocks' which provide an index of how much an individual's biological age differs from their chronological age at the time of measurement. The five clocks encompass methylation-based predictors of chronological age (HorvathAge, HannumAge), all-cause mortality (DNAm PhenoAge, DNAm GrimAge) and telomere length (DNAm Telomere Length). A sixth epigenetic measure of ageing differs from these clocks in that it acts as a speedometer providing a single time-point measurement of the pace of an individual's biological ageing. This measure of ageing is termed DunedinPoAm. In this study, we test the association between these six epigenetic measures of ageing and the prevalence and incidence of the leading causes of disease burden and mortality in high-income countries (n ≤ 9537, Generation Scotland: Scottish Family Health Study). DNAm GrimAge predicted incidence of clinically diagnosed chronic obstructive pulmonary disease (COPD), type 2 diabetes and ischemic heart disease after 13 years of foll...Continue Reading

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Mentioned in this Paper

DNA Binding
Follow-up
Spirometry
Diabetes Mellitus, Non-Insulin-Dependent
Study
Chronic Obstructive Airway Disease
Myocardial Ischemia
Family Research
Malignant Neoplasm of Lung
Cessation of Life

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