Epigenetic mechanisms in odontogenic tumors: A literature review

Archives of Oral Biology
Jorge Sandoval-BasilioNicolás Serafín-Higuera

Abstract

Epigenetic mechanisms, such as DNA methylation, regulate important biological processes as gene expression and it was suggested that these phenomena play important roles in the carcinogenesis and tumor biology. The aim of this review is to provide the current state of knowledge about epigenetic alterations, focusing mainly on DNA methylation, reported in odontogenic tumors. Literatures were searched based in the combination of the following keywords: odontogenic tumors, epigenetics, DNA methylation, histone modifications, non-coding RNA, microRNA, DNA methyltransferases. Electronic databases (Medline/PubMed, Scopus and Web of Science) were screened. The analysis of epigenetic alterations in different tumors has rapidly increased; however, limited information is available about epigenetic mechanisms involved in the formation of odontogenic tumors. DNA methylation is the most studied epigenetic modification in these tumors and the participation of non-coding RNA's in odontogenic tumors has been recently addressed. Differential expression of DNA methyltransferases, altered DNA methylation patterns and aberrant expression of non-coding RNA's were reported in odontogenic tumors. Current studies suggest epigenetics as an emerging mec...Continue Reading

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Citations

Jan 5, 2020·International Journal of Oral Science·Angustias PageAngel Ramirez
Aug 14, 2019·Frontiers in Immunology·Gabriela Leija MontoyaNicolás Serafín Higuera
Dec 5, 2018·Reviews in Medical Virology·Javad CharostadEbrahim Faghihloo
Dec 5, 2019·World Journal of Clinical Cases·Hussein SabitHuseyin Tombuloglu
Apr 7, 2021·Molecular Biology Reports·Alieh FarshbafNooshin Mohtasham
Apr 27, 2021·Oral Diseases·Gleyson Kleber do Amaral-SilvaPablo Agustin Vargas
Jan 30, 2019·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Celeste Sánchez-RomeroRonell Bologna-Molina

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