Epigenetic mechanisms of tumor resistance to immunotherapy

Cellular and Molecular Life Sciences : CMLS
Natalia Arenas-RamirezOnur Boyman

Abstract

The recent impact of cancer immunotherapies has firmly established the ability and importance of the immune system to fight malignancies. However, the intimate interaction between the highly dynamic tumor and immune cells leads to a selection process driven by genetic and epigenetic processes. As the molecular pathways of cancer resistance mechanisms to immunotherapy become increasingly known, novel therapeutic targets are being tested in combination with immune-stimulating approaches. We here review recent insights into the molecular mechanisms of tumor resistance with particular emphasis on epigenetic processes and place these in the context of previous models.

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Citations

Jul 5, 2019·Nature Reviews. Molecular Cell Biology·Ewa M MichalakMark A Dawson
Oct 12, 2020·Journal of Leukocyte Biology·Fang-Fei ShaoGuo-Qing Wu
Aug 10, 2019·Cancer Research·Hongping DongBin Zou
Dec 24, 2020·Nature Communications·Dilara SahinOnur Boyman
Nov 17, 2021·Cancer Immunology Research·Lisa C WellingerRicky W Johnstone

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Methods Mentioned

BETA
acetylation
histone acetylation
histone

Clinical Trials Mentioned

NCT03179943
NCT02664181

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