Epigenetic mechanisms underlying prostate cancer radioresistance.

Clinical Epigenetics
Catarina Macedo-SilvaLucia Altucci

Abstract

Radiotherapy (RT) is one of the mainstay treatments for prostate cancer (PCa), a highly prevalent neoplasm among males worldwide. About 30% of newly diagnosed PCa patients receive RT with a curative intent. However, biochemical relapse occurs in 20-40% of advanced PCa treated with RT either alone or in combination with adjuvant-hormonal therapy. Epigenetic alterations, frequently associated with molecular variations in PCa, contribute to the acquisition of a radioresistant phenotype. Increased DNA damage repair and cell cycle deregulation decreases radio-response in PCa patients. Moreover, the interplay between epigenome and cell growth pathways is extensively described in published literature. Importantly, as the clinical pattern of PCa ranges from an indolent tumor to an aggressive disease, discovering specific targetable epigenetic molecules able to overcome and predict PCa radioresistance is urgently needed. Currently, histone-deacetylase and DNA-methyltransferase inhibitors are the most studied classes of chromatin-modifying drugs (so-called 'epidrugs') within cancer radiosensitization context. Nonetheless, the lack of reliable validation trials is a foremost drawback. This review summarizes the major epigenetically induce...Continue Reading

References

Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Alan E NahumJ Donald Chapman
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Timothy M Pawlik, Khandan Keyomarsi
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jing FangBing-Hua Jiang
Jul 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Khanh H NguyenAlan Pollack
Jul 20, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Alice X MengRobert G Bristow
Apr 7, 2007·Cancer Metastasis Reviews·Ranjit S BindraPeter M Glazer
Nov 26, 2008·Epigenetics : Official Journal of the DNA Methylation Society·Ata Abbas, Sanjay Gupta
Sep 16, 2009·Carcinogenesis·Shikhar SharmaPeter A Jones
Feb 6, 2010·Stem Cells·Frank PajonkWilliam H McBride
Dec 25, 2010·International Journal of Radiation Oncology, Biology, Physics·David J CarlsonJ Martin Brown
May 17, 2011·Molecular Cancer Therapeutics·Juan Camilo Barreto-AndradeRalph R Weichselbaum
May 21, 2011·International Journal of Radiation Oncology, Biology, Physics·Daniel J KraussAlvaro A Martinez
Apr 20, 2012·The Prostate·Yong Mee ChoElaine M Hurt
Jun 23, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Christine A ArmstrongCristina Tufarelli
Aug 8, 2012·Molecular Cancer·Francesco CreaCheryl D Helgason
Sep 13, 2012·Acta Oncologica·Alexandru Dasu, Iuliana Toma-Dasu
Oct 2, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Toshiaki ShinojimaLaurent Lessard
Oct 3, 2012·Oncology Reports·Xiaobin WangHaijun Shi
Jan 10, 2013·European Journal of Human Genetics : EJHG·Yang ChenYanling Hu
Jan 11, 2013·Journal of Cellular and Molecular Medicine·Murielle Mimeault, Surinder K Batra
Mar 28, 2013·Prostate Cancer·L Chinsoo ChoBrian Kavanagh
May 29, 2013·Nature Reviews. Urology·Laure MarignolDonal Hollywood
Jul 23, 2013·International Journal of Molecular Sciences·Joong-Gook KimJoo Mi Yi
Nov 10, 2013·Neoplasia : an International Journal for Oncology Research·Sumin HanFelix Y Feng
Nov 13, 2013·The Journal of Cell Biology·Nima MosammaparastYang Shi
Mar 4, 2014·Expert Review of Anticancer Therapy·Berardino De BariFilippo Alongi
Apr 15, 2014·Journal of Neuro-oncology·Wenyin ShiAdam P Dicker
May 2, 2014·Journal of Cellular and Molecular Medicine·Jasmina MakarevićRoman A Blaheta
Nov 12, 2014·Prostate Cancer and Prostatic Diseases·R ZelicL Richiardi
Feb 12, 2015·The Journal of Biological Chemistry·Krystal D NolanJennifer S Isaacs
Mar 11, 2015·Clinical Oncology : a Journal of the Royal College of Radiologists·K J RayA E Kiltie

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