Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part I)

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Fuzhou WangRichard M Kream

Abstract

DRG is of importance in relaying painful stimulation to the higher pain centers and therefore could be a crucial target for early intervention aimed at suppressing primary afferent stimulation. Complex regional pain syndrome (CRPS) is a common pain condition with an unknown etiology. Recently added new information enriches our understanding of CRPS pathophysiology. Researches on genetics, biogenic amines, neurotransmitters, and mechanisms of pain modulation, central sensitization, and autonomic functions in CRPS revealed various abnormalities indicating that multiple factors and mechanisms are involved in the pathogenesis of CRPS. Epigenetics refers to mitotically and meiotically heritable changes in gene expression that do not affect the DNA sequence. As epigenetic modifications potentially play an important role in inflammatory cytokine metabolism, neurotransmitter responsiveness, and analgesic sensitivity, they are likely key factors in the development of chronic pain. In this dyad review series, we systematically examine the nerve injury-related changes in the neurological system and their contribution to CRPS. In this part, we first reviewed and summarized the role of neural sensitization in DRG neurons in performing funct...Continue Reading

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Citations

Jul 18, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·George B StefanoRichard M Kream
May 23, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·George B Stefano, Richard M Kream
May 26, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Christopher Snyder, George B Stefano
Nov 6, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Tijs LouwiesBeverley Greenwood-Van Meerveld
Jun 18, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Ajax Yang, Corey W Hunter
Jan 29, 2016·International Journal of Molecular Medicine·George B Stefano, Richard M Kream

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