Epigenetic modulation associated with carcinogenesis and prognosis of human gastric cancer

Oncology Letters
Fuminori SonoharaShuji Nomoto

Abstract

Gastric cancer (GC) is a leading cause of cancer-related death, particularly in Asia. Epidemiological and other clinical studies have identified an association between a number of risk factors, including Helicobacter pylori, and GC. A number of studies have also examined genetic changes associated with the development and progression of GC. When considering the clinical significance of the expression of a specific gene, its epigenetic modulation should be considered. Epigenetic modulation appears to be a primary driver of changes in gastric tissue that promotes carcinogenesis and progression of GC and other neoplasms. The role of epigenetic modulation in GC carcinogenesis and progression has been widely studied in recent years. In the present review, recent results of epigenetic modulation associated with GC and their effects on clinical outcome are examined, with particular respect to DNA methylation, histone modulation and non-coding RNA. A number of studies indicate that epigenetic changes in the expression of specific genes critically affect their clinical significance and further study may reveal epigenetic changes as the basis for targeted molecular therapy or novel biomarkers that predict GC prognosis or extension of thi...Continue Reading

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Citations

Dec 31, 2020·International Journal of Molecular Sciences·Ahmed MalkiAla-Eddin Al Moustafa
Mar 17, 2020·Gene·Vida EbrahimiVahideh Tarhriz
Jun 3, 2021·International Journal of Molecular Sciences·Irina V Bure, Marina V Nemtsova
Sep 28, 2021·Frontiers in Molecular Biosciences·Cheng ZhangDong-Qiu Dai

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