Epigenetic modulation at the CCR2 gene correlates with the maintenance of behavioral sensitization to methamphetamine

Addiction Biology
Daigo IkegamiTsutomu Suzuki

Abstract

The intermittent administration of methamphetamine produces behavioral sensitization to methamphetamine. In the limbic forebrain, mainly including the nucleus accumbens, of mice that had been intermittently treated with methamphetamine, we found a significant increase in mRNA of a chemokine, CCR2. This increase was accompanied by a significant increase in histone H3 lysine 4 (H3K4) trimethylation at its promoter. Interestingly, the maintenance of sensitization to methamphetamine-induced hyperlocomotion was significantly decreased in CCR2 knockout mice. These findings suggest that increased CCR2 associated with epigenetic modification after the intermittent administration of methamphetamine may be associated with the maintenance of sensitization to methamphetamine-induced hyperlocomotion.

References

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Citations

Mar 23, 2011·Journal of Molecular Neuroscience : MN·Jean Marc TrocelloEmmanuelle Apartis
Sep 21, 2011·Addiction Biology·Sandra Helinski, Rainer Spanagel
May 30, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Arthur GodinoJean Lud Cadet
Feb 4, 2016·Clinical Pharmacology and Therapeutics·J L CadetS Jayanthi
Nov 6, 2014·Biomolecular Concepts·Norikazu KiguchiShiroh Kishioka
Jan 20, 2021·Drug and Alcohol Dependence·Olivia C AhearnScott M Rawls

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