Epigenetic modulations and lineage plasticity in advanced prostate cancer

Annals of Oncology : Official Journal of the European Society for Medical Oncology
R GeL Cheng

Abstract

Prostate cancer is the most common cancer and second leading cause of cancer-related death in American men. Antiandrogen therapies are part of the standard of therapeutic regimen for advanced or metastatic prostate cancers; however, patients who receive these treatments are more likely to develop castration-resistant prostate cancer (CRPC) or neuroendocrine prostate cancer (NEPC). In the development of CRPC or NEPC, numerous genetic signaling pathways have been under preclinical investigations and in clinical trials. Accumulated evidence shows that DNA methylation, chromatin integrity, and accessibility for transcriptional regulation still play key roles in prostate cancer initiation and progression. Better understanding of how epigenetic change regulates the progression of prostate cancer and the interaction between epigenetic and genetic modulators driving NEPC may help develop a better risk stratification and more effective treatment regimens for prostate cancer patients.

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Citations

Jun 14, 2020·Signal Transduction and Targeted Therapy·Weiwei TangXuehao Wang
Jan 13, 2021·Current Oncology Reports·Yasutaka Yamada, Himisha Beltran
Feb 10, 2021·International Journal of Molecular Sciences·Matteo RoselliniFrancesco Massari
Feb 6, 2021·Seminars in Cancer Biology·Sakshi GoelBushra Ateeq
Apr 4, 2021·Cancers·Anaís Sánchez-CastilloKim R Kampen
Oct 23, 2020·Cancer Treatment and Research Communications·Carlo CattriniPaola Barboro
Jun 17, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Mariana Brütt PachecoCarmen Jerónimo
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Zhao-Ming XiaoShan-Chao Zhao
Aug 17, 2021·Frontiers in Cell and Developmental Biology·Shengxian XuHongtuan Zhang

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