Epigenetic Patterns Modulate the Connection Between Developmental Dynamics of Parenting and Offspring Psychosocial Adjustment

Child Development
Oksana Yu NaumovaElena L Grigorenko

Abstract

This study attempted to establish and quantify the connections between parenting, offspring psychosocial adjustment, and the epigenome. The participants, 35 African American young adults (19 females and 16 males; age = 17-29.5 years), represented a subsample of a 3-wave longitudinal 15-year study on the developmental trajectories of low-income urban mother-offspring dyads. Mothers were assessed on their perceptions of maternal stress at each wave. Offspring were assessed on their perceptions of maternal parenting at each wave and on their adaptive and maladaptive behavior at the last wave. Genome-wide DNA methylation in peripheral T lymphocytes at the third wave was assayed using Methyl Binding Domain(MBD) sequencing. Statistically significant associations were identified between the change in offspring's perception of parenting from middle childhood to adulthood and the DNA methylation in offspring's adult genomes. Specifically, the slope of perceived parental rejection across the 3 time points was related to an increase in methylation, or a potential downregulation, of 565 genes thought to be involved in the control of a broad spectrum of biological functions generally related to cellular signaling. A subset of these epigenet...Continue Reading

References

May 24, 1997·Biochimica Et Biophysica Acta·F CarlucciA Tabucchi
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
Jul 13, 2007·Immunological Reviews·Juergen S ScheeleGerry R Boss
Dec 21, 2007·Environmental and Molecular Mutagenesis·Moshe SzyfMichael J Meaney
Feb 24, 2009·Nature Neuroscience·Patrick O McGowanMichael J Meaney
Jun 26, 2010·Development and Psychopathology·Martha J CoxJean-Louis Gariépy
May 28, 2011·Annals of the New York Academy of Sciences·Barry M LesterMarcelo A Wood
Oct 11, 2011·Journal of Neurodevelopmental Disorders·Frank H Bloomfield
Mar 17, 2012·International Journal of Epidemiology·Nada BorgholMoshe Szyf
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Michael Rutter
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Jul 24, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Moshe Szyf
Sep 14, 2013·International Journal of Environmental Research and Public Health·Dario SiniscalcoNicola Antonucci
Mar 13, 2014·BMC Medical Genomics·Matthew SudermanMoshe Szyf
Jun 16, 2014·Biological Psychiatry·Emma L DempsterThalia C Eley

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Citations

Jan 30, 2016·Child Development·Barry M LesterCarmen Marsit
Sep 10, 2019·European Journal of Psychotraumatology·Patricia DashorstRafaele J C Huntjens
May 1, 2018·Journal of Clinical and Translational Science·Michelle L WrightJacquelyn Y Taylor
Sep 16, 2018·Scientific Reports·Andressa BortoluzziGisele Gus Manfro
Jul 24, 2018·Frontiers in Medicine·Jessica L BorelliPeter Fonagy
Jul 25, 2020·Epigenomics·Bernardo J KrauseJames Hamilton
Feb 6, 2017·Journal of Personality Assessment·Karin EnsinkPeter Fonagy
Dec 15, 2020·Journal of Developmental Origins of Health and Disease·Rocio ArtigasBernardo J Krause
Aug 2, 2021·Developmental Psychobiology·Sarah M MerrillNicole L Letourneau
Nov 26, 2021·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Amanda Sheffield MorrisLaurence Steinberg

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