Epigenetic prediction of major depressive disorder.

Molecular Psychiatry
Miruna C BarbuAndrew M McIntosh

Abstract

Variation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking and body mass index (BMI) but there has been little research exploring its ability to identify individuals with major depressive disorder (MDD). Using penalised regression on genome-wide CpG methylation, we tested whether DNAm risk scores (MRS), trained on 1223 MDD cases and 1824 controls, could discriminate between cases (n = 363) and controls (n = 1417) in an independent sample, comparing their predictive accuracy to polygenic risk scores (PRS). The MRS explained 1.75% of the variance in MDD (β = 0.338, p = 1.17 × 10-7) and remained associated after adjustment for lifestyle factors (β = 0.219, p = 0.001, R2 = 0.68%). When modelled alongside PRS (β = 0.384, p = 4.69 × 10-9) the MRS remained associated with MDD (β = 0.327, p = 5.66 × 10-7). The MRS was also associated with incident cases of MDD who were well at recruitment but went on to develop MDD at a later assessment (β = 0.193, p = 0.016, R2 = 0.52%). Heritability analyses found additive genetic effects explained 22% of variance in the MRS, with a further 19% explained by pedigree-associated genetic effects and 16% by the shared couple environment. Smoking status was also strongly asso...Continue Reading

References

Oct 25, 2002·American Journal of Epidemiology·Karen LeffondréBernard Rachet
Oct 7, 2004·The Medical Clinics of North America·Khatija N PaperwallaStephen M Saravay
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
May 14, 2010·Psychiatry Research·Leonore de WitPim Cuijpers
Apr 5, 2012·Molecular Psychiatry·UNKNOWN Major Depressive Disorder Working Group of the Psychiatric GWAS ConsortiumPatrick F Sullivan
May 2, 2013·BMC Genomics·Ruth PidsleyLeonard C Schalkwyk
Nov 20, 2013·Comprehensive Psychiatry·Frédéric N BrièrePeter M Lewinsohn
Oct 7, 2014·F1000Research·Jean-Philippe FortinKasper Hansen
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Dec 15, 2015·Nature Communications·Oriol Canela-XandriAlbert Tenesa
Oct 21, 2016·Circulation. Cardiovascular Genetics·Roby JoehanesStephanie J London
Nov 16, 2016·Molecular Psychiatry·C LiuD Levy
Nov 4, 2017·Journal of Clinical Epidemiology·Jonathan D HaffertyAndrew M McIntosh
Dec 1, 2017·Nature Communications·Kyoko WatanabeDanielle Posthuma
Apr 28, 2018·Nature Genetics·Naomi R WrayUNKNOWN Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
May 5, 2018·Bioinformatics·Wenwen MinShihua Zhang
Sep 28, 2018·Genome Biology·Daniel L McCartneyRiccardo E Marioni
Nov 6, 2018·EBioMedicine·Daniel L McCartneyRiccardo E Marioni
Nov 27, 2019·Molecular Psychiatry·Toni-Kim ClarkeAndrew M McIntosh
Jan 9, 2020·Nature Communications·Jung-Min OhGideon Dreyfuss
Feb 21, 2019·BioRxiv : the Preprint Server for Biology·Toni-Kim ClarkeA. McIntosh

❮ Previous
Next ❯

Citations

Nov 23, 2020·Brain, Behavior, and Immunity·Claire GreenHeather C Whalley
Mar 9, 2021·Psychological Medicine·K M KendallY Lu
Apr 20, 2021·Frontiers in Psychiatry·Anna Starnawska, Ditte Demontis
May 13, 2021·Wellcome Open Research·Robert F Hillary, Riccardo E Marioni
Sep 16, 2021·Human Molecular Genetics·David M HowardCathryn M Lewis
Oct 13, 2021·Addiction Biology·Sunniva M K BøstrandToni-Kim Clarke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.