Epigenetic primer for diagnostic applications: a window into personalized medicine

Personalized Medicine
Beth McNallyRoland Valdes

Abstract

Epigenetic testing, primarily in the form of DNA methylation analysis, is currently being used in healthcare settings to help identify and manage disease conditions and to develop and select drugs that specifically target epigenetic machinery. Yet, the clinical application of epigenetic analysis is still in its infancy. With a number of large-scale national and international epigenomic consortia projects in progress to identify tissue-specific epigenomes in normal and disease conditions, we are now poised for a new era of understanding disease processes based upon genetic changes that do not involve alterations to the DNA sequence. The developing epigenetic knowledge base will significantly advance the practice of personalized medicine and precision therapeutics. In this article, we provide a primer on the fundamentals of epigenetics with an emphasis on DNA methylation and review the prospective uses of epigenetic testing in advancing healthcare.

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Dec 26, 2017·Current Opinion in Biotechnology·Kerry R LoveJ Christopher Love

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Methods Mentioned

BETA
genetic modification
targeted mutation
MDS
PCR
genotyping
biopsy
bronchoalveolar
lavage

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