Epigenetic reactivation of p21CIP1/WAF1 and KLOTHO by a combination of bioactive dietary supplements is partially ERα-dependent in ERα-negative human breast cancer cells.

Molecular and Cellular Endocrinology
Sonam SinhaSyed M Meeran

Abstract

Available treatment strategies against estrogen receptor (ER)-negative breast cancer patients are limited due to their poor response to hormonal therapy. We have shown previously that the combinations of green tea polyphenols (GTPs), a dietary DNA methyltransferase inhibitor, and sulforaphane (SFN), a dietary histone deacetylase inhibitor, reactivate ERα expression in ERα-negative MDA-MB-231 cells. Here, we investigated the functional significance of ERα reactivation in the reactivation of silenced tumor suppressor genes (TSGs) in ERα-negative human breast cancer cells. We found that the treatment of MDA-MB-231 cells with the combinations of GTPs and SFN leads to the reactivation of silenced TSGs such as p21(CIP1/WAF1) and KLOTHO through active chromatin modifications. Further, GTPs- and SFN-mediated reactivation of TSGs was, at least in part, dependent on ERα reactivation in ERα-negative MDA-MB-231 cells. Collectively, our findings suggest that a novel combination of bioactive dietary supplements could further be explored as an effective therapeutic option against hormonal refractory breast cancer.

References

Aug 3, 2002·Oncogene·Peter A Jones
Dec 13, 2002·Cell Death and Differentiation·M CastedoG Kroemer
Nov 20, 2003·Nature Reviews. Molecular Cell Biology·Steven I Reed
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Feb 28, 2004·The Journal of Pharmacology and Experimental Therapeutics·Rong HuA-N Tony Kong
Apr 13, 2004·Oncogene·Maria CastedoGuido Kroemer
Aug 16, 2005·Current Opinion in Genetics & Development·François Fuks
Jun 9, 2007·Seminars in Cancer Biology·Roderick H Dashwood, Emily Ho
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Syed Musthapa Meeran, Santosh Kumar Katiyar
Nov 26, 2008·Nature Reviews. Cancer·Michael Pollak
Aug 12, 2009·International Journal of Colorectal Disease·Kamal YavariMohammad Hossein Babaei
Apr 28, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie PanLiang Jing Wang
Sep 23, 2011·Molecular & Cellular Proteomics : MCP·François-Michel BoisvertAngus I Lamond
Nov 2, 2011·Breast Cancer Research and Treatment·Tami RubinekIdo Wolf
Jul 6, 2013·Pathology Oncology Research : POR·Biao XieJunkun Zhan
Dec 4, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hyun Soo ParkYung Hyun Choi

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Citations

Dec 10, 2015·Oxidative Medicine and Cellular Longevity·Anna Maria Mileo, Stefania Miccadei
May 24, 2016·The International Journal of Biochemistry & Cell Biology·Sonam SinhaSyed Musthapa Meeran
May 5, 2016·Molecular Nutrition & Food Research·Donato F RomagnoloOrnella I Selmin
Jun 15, 2018·International Journal of Molecular Sciences·Bidisha PaulTrygve O Tollefsbol
Oct 14, 2018·Experimental Dermatology·Abdullah Alyoussef, Medhat Taha
Feb 27, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yanning LiWangsen Cao
Oct 5, 2017·Photodermatology, Photoimmunology & Photomedicine·Dhanamjai PentaSyed Musthapa Meeran
Sep 22, 2019·International Journal of Molecular Sciences·Itika AroraTrygve O Tollefsbol
May 5, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Md Sadikuj Jaman, Md Abu Sayeed
Jun 21, 2019·Medicinal Research Reviews·Daniela TomaselliAntonello Mai
Oct 22, 2020·Critical Reviews in Food Science and Nutrition·Ankita KumariRajeev Kapila
Nov 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Parham Jabbarzadeh KaboliZhangang Xiao
Feb 2, 2021·Frontiers in Cell and Developmental Biology·Franz EwendtMichael Föller
Jul 16, 2017·Advanced Drug Delivery Reviews·Rik MenckeJan-Luuk Hillebrands
Dec 16, 2021·Journal of Agricultural and Food Chemistry·Dheeran RajarajanSyed Musthapa Meeran

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