Epigenetic regulation in the inner ear and its potential roles in development, protection, and regeneration

Frontiers in Cellular Neuroscience
Wanda S Layman, Jian Zuo

Abstract

The burgeoning field of epigenetics is beginning to make a significant impact on our understanding of tissue development, maintenance, and function. Epigenetic mechanisms regulate the structure and activity of the genome in response to intracellular and environmental cues that direct cell-type specific gene networks. The inner ear is comprised of highly specialized cell types with identical genomes that originate from a single totipotent zygote. During inner ear development specific combinations of transcription factors and epigenetic modifiers must function in a coordinated manner to establish and maintain cellular identity. These epigenetic regulatory mechanisms contribute to the maintenance of distinct chromatin states and cell-type specific gene expression patterns. In this review, we highlight emerging paradigms for epigenetic modifications related to inner ear development, and how epigenetics may have a significant role in hearing loss, protection, and regeneration.

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Citations

Nov 21, 2020·International Journal of Molecular Sciences·Xin Deng, Zhengqing Hu
Mar 20, 2021·Journal of Proteomics·Rajani G TumaneDhananjay V Raje
Jul 27, 2021·Neural Plasticity·Chang LiuYingzi He
Sep 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yushi HayashiAlbert S B Edge

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Methods Mentioned

BETA
acetylation
histone acetylation
deamination
RNA-seq

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