Epigenetic Regulation of ATP-Binding Cassette Protein A1 (ABCA1 ) Gene Expression: A New Era to Alleviate Atherosclerotic Cardiovascular Disease

Diseases
Mohamed Zaiou, Ahmed Bakillah

Abstract

The most important function of high density lipoprotein (HDL) is its ability to remove cholesterol from cells and tissues involved in the early stages of atherosclerosis back to the liver for excretion. The ATP-binding cassette transporters ABCA1 and ABCG1 are responsible for the major part of cholesterol efflux to HDL in macrophage foam cells. Thus, promoting the process of reverse cholesterol transport (RCT) by upregulating mainly ABCA1 remains one of the potential targets for the development of new therapeutic agents against atherosclerosis. Growing evidence suggests that posttranscriptional regulation of HDL biogenesis as well as modulation of ABCA1 expression are under the control of several genetic and epigenetic factors such as transcription factor (TFs), microRNAs (miRNAs) and RNA-binding proteins (RBPs).These factors may act either individually or in combination to orchestrate ABCA1 expression. Complementary to our recent work, we propose an exploratory model for the potential molecular mechanism(s) underlying epigenetic signature of ABCA1 gene regulation. Such a model may hopefully provide the basic framework for understanding the epigenetic regulation of RCT and contribute to the development of novel therapeutic stra...Continue Reading

References

Mar 18, 2008·FEBS Letters·Tina GlisovicGideon Dreyfuss
Mar 11, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Natalia J Martinez, Albertha J M Walhout
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·Veerle Rottiers, Anders M Näär
Mar 23, 2013·Circulation Research·Cristina M RamírezCarlos Fernández-Hernando
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sarah PicaudPanagis Filippakopoulos
Apr 15, 2014·Journal of Lipid Research·Cristina M RamírezCarlos Fernández-Hernando
Sep 22, 2015·Frontiers in Pharmacology·Kuang-Yuh Chyu, Prediman K Shah
Aug 20, 2016·Nature Communications·Lesca M HoldtDaniel Teupser
Jul 6, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Zhen-Guo YangBurton B Yang
Nov 25, 2017·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M ZaiouA Bakillah
May 18, 2018·Frontiers in Bioscience (Landmark Edition)·Mohamed ZaiouAhmed Bakillah

❮ Previous
Next ❯

Citations

Dec 20, 2018·Journal of Personalized Medicine·Luis A López-Fernández
Jul 16, 2020·Non-coding RNA·Marcin WysoczynskiShizuka Uchida
Jun 27, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mohamed Zaiou
Feb 5, 2021·Journal of Atherosclerosis and Thrombosis·Xiaomei LuDongfeng Gu

❮ Previous
Next ❯

Software Mentioned

ASSURE
SUSTAIN
CircInteractome

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.