Epigenetic Regulation of Autophagy: A Path to the Control of Autoimmunity

Frontiers in Immunology
Jessica C Hargarten, Peter R Williamson

Abstract

Autoimmune diseases are a significant cause of debilitation and mortality globally and are in need of cost-effective therapeutics. Autophagy is a cellular pathway that facilitates immune modulation involved in both pathogen control and autoimmunity. Regulation is multifactorial and includes a number of epigenetic pathways which can involve modification of DNA-binding histones to induce autophagy-related mRNA synthesis or microRNA and decapping-associated mRNA degradation which results in autophagy suppression. Appreciation of epigenetic-based pathways involved in autophagy and autoimmunity may facilitate application of a burgeoning group of epigenetic pharmaceuticals to these important diseases.

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Citations

Mar 29, 2019·Current Opinion in Rheumatology·Eric Liu, Andras Perl
Aug 19, 2020·Antioxidants & Redox Signaling·Stefano MasiSarah Costantino
May 31, 2019·Human Genetics·Shi Q WongLouis R Lapierre
Aug 25, 2019·Trends in Endocrinology and Metabolism : TEM·Zhiyong Cheng
Jan 11, 2022·Epigenetics : Official Journal of the DNA Methylation Society·Tomasz PodgorniakJorge Fernandes

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Methods Mentioned

BETA
ubiquitination
glycosylation
acetylation
GTPase
lipidation

Software Mentioned

DICER

Related Concepts

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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