Epigenetic regulation of cardiac fibrosis

Journal of Molecular and Cellular Cardiology
Matthew S Stratton, Timothy A McKinsey

Abstract

Fibrosis is defined as excess deposition of extracellular matrix (ECM), resulting in tissue scarring and organ dysfunction. In the heart, fibrosis may be reparative, replacing areas of myocyte loss with a structural scar following infarction, or reactive, which is triggered in the absence of cell death and involves interstitial ECM deposition in response to long-lasting stress. Interstitial fibrosis can increase the passive stiffness of the myocardium, resulting in impaired relaxation and diastolic dysfunction. Additionally, fibrosis can lead to disruption of electrical conduction in the heart, causing arrhythmias, and can limit myocyte oxygen availability and thus exacerbate myocardial ischemia. Here, we review recent studies that have illustrated key roles for epigenetic events in the control of pro-fibrotic gene expression, and highlight the potential of small molecules that target epigenetic regulators as a means of treating fibrotic cardiac diseases.

References

Jan 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E M Bradbury
Jun 13, 2003·Trends in Genetics : TIG·Michael J CarrozzaJacques Côté
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yuzuru Shiio, Robert N Eisenman
Mar 10, 2004·The International Journal of Biochemistry & Cell Biology·Rosalind J GustersonDavid S Latchman
Mar 31, 2004·Journal of Molecular Biology·Ivan V GregorettiHolly V Goodson
Dec 24, 2005·Nature·John F FlanaganSepideh Khorasanizadeh
Mar 17, 2007·Annual Review of Biochemistry·Mona D Shahbazian, Michael Grunstein
Aug 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dwayne A BisgroveEric Verdin
Nov 7, 2007·Nature Structural & Molecular Biology·Sean D TavernaDinshaw J Patel
Feb 23, 2008·The Journal of Clinical Investigation·Tatsuya MorimotoKoji Hasegawa
Aug 14, 2008·Circulation·Jian Qin WeiNanette H Bishopric
Dec 22, 2009·Nature Structural & Molecular Biology·John R HortonXiaodong Cheng
Feb 6, 2010·Circulation Research·Erik W Bush, Timothy A McKinsey
Mar 20, 2010·Genes & Development·Blerta Xhemalce, Tony Kouzarides
May 27, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jon-Jon SantiagoIan M C Dixon
Jun 11, 2010·Chemistry & Biology·Melanie Ott, Eric Verdin
Oct 12, 2010·Journal of the American Society of Nephrology : JASN·Guangdong SunRama Natarajan
Feb 4, 2011·Genes & Development·Anh T NguyenYi Zhang
May 5, 2011·Journal of Molecular and Cellular Cardiology·Douglas D LemonTimothy A McKinsey
Dec 14, 2011·Circulation Research·Aibin HeWilliam T Pu
Mar 6, 2012·Molecular & Cellular Proteomics : MCP·Zhongyu XieYingming Zhao
Apr 11, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maria Jesus PerugorriaJelena Mann
Aug 24, 2012·Annals of the Rheumatic Diseases·Marlene KrämerJörg H W Distler
Nov 13, 2012·Journal of Molecular and Cellular Cardiology·Ravi K AdapalaCharles K Thodeti
Nov 16, 2012·The Journal of Biological Chemistry·Sivakumar RamadossCun-Yu Wang

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Citations

Aug 25, 2016·Future Medicinal Chemistry·Katherine B SchuetzeTimothy A McKinsey
Mar 19, 2019·Circulation. Arrhythmia and Electrophysiology·Beatrix ScholzFrank Ulrich Müller
Feb 9, 2017·The Journal of Pharmacology and Experimental Therapeutics·Katherine B SchuetzeTimothy A McKinsey
Feb 14, 2018·Science Translational Medicine·Mark Y JeongTimothy A McKinsey
Apr 6, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Vincent F M SegersGilles W De Keulenaer
Feb 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Viviana Pardo-JiménezGuillermo Díaz-Araya
Oct 3, 2018·Current Pathobiology Reports·Thu Elizabeth Duong, James S Hagood
Mar 7, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yukun LiuChristine G Lian
Jan 2, 2019·International Journal of Molecular Sciences·Justine Habibian, Bradley S Ferguson
Nov 3, 2020·Cardiovascular Research·Nikolaos G Frangogiannis
Feb 2, 2021·Chemical & Pharmaceutical Bulletin·Xiaoling WangHan Xie
Feb 13, 2021·Life Sciences·Xuping LiYuanyuan Cheng
Jul 30, 2018·Molecular Aspects of Medicine·Nikolaos G Frangogiannis
Mar 21, 2021·Free Radical Biology & Medicine·Changhai TianIrving H Zucker
May 14, 2021·Advanced Drug Delivery Reviews·Fabiana PassaroGianluca Testa
Jun 4, 2021·Circulation Research·Jin-Ling HuoWen Zhao
Jun 14, 2021·Journal of Molecular and Cellular Cardiology·Luis AlgecirasAna V Villar

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