Epigenetic regulation of early neural fate commitment

Cellular and Molecular Life Sciences : CMLS
Yunbo QiaoNaihe Jing

Abstract

Early neural fate commitment is a key process in neural development and establishment of the central nervous system, and this process is tightly controlled by extrinsic signals, intrinsic factors, and epigenetic regulation. Here, we summarize the main findings regarding the regulatory network of epigenetic mechanisms that play important roles during early neural fate determination and embryonic development, including histone modifications, chromatin remodeling, DNA modifications, and RNA-level regulation. These regulatory mechanisms coordinate to play essential roles in silencing of pluripotency genes and activating key neurodevelopmental genes during cell fate commitment at DNA, histone, chromatin, and RNA levels. Moreover, we discuss the relationship between epigenetic regulation, signaling pathways, and intrinsic factors during early neural fate specification.

References

Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R Martin
Jul 27, 1995·Nature·P A Wilson, A Hemmati-Brivanlou
Nov 6, 1998·Science·J A ThomsonJ M Jones
Jan 19, 2000·Nature·B D Strahl, C D Allis
Aug 11, 2001·Science·T Jenuwein, C D Allis
Nov 1, 2001·Nature Neuroscience·S I Wilson, T Edlund
Nov 2, 2001·Nature·S Temple
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Jan 28, 2003·Biochemical Society Transactions·M P Stavridis, A G Smith
Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Jan 1, 2004·Genes & Development·Edgar M PeraEddy M De Robertis
May 28, 2004·Nature·Gerda EggerPeter A Jones
Jun 3, 2004·Current Opinion in Genetics & Development·Kyoung Sang ChoCornelius F Boerkoel
Sep 17, 2004·Nature·Victor Ambros
Nov 4, 2004·Trends in Genetics : TIG·Peizhang XuBruce A Hay
Mar 31, 2005·Current Opinion in Genetics & Development·Raphael MargueronDanny Reinberg
Apr 6, 2005·Human Molecular Genetics·John S Mattick, Igor V Makunin
Apr 23, 2005·The European Journal of Neuroscience·Lena SmirnovaF Gregory Wulczyn
Sep 2, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lei WangMichael Chopp
Sep 6, 2005·Science·John S Mattick
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Nov 18, 2005·Gene·Michele A GlozakEdward Seto
Dec 17, 2005·Stem Cells·Anna M KrichevskyKenneth S Kosik
Mar 30, 2006·Nature Cell Biology·Véronique AzuaraAmanda G Fisher
May 26, 2006·Nature Reviews. Molecular Cell Biology·James A Goodrich, Jennifer F Kugel
Jun 14, 2006·Brain Pathology·Su-Chun Zhang
Feb 28, 2007·Cell Research·Paola GallinariChristian Steinkühler

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Citations

Dec 17, 2017·Human Genomics·Alexander M Vaiserman, Alexander K Koliada
Dec 29, 2017·The EMBO Journal·Domenico RussoGiovanni D'Angelo
Jan 13, 2018·PLoS Genetics·Carolyn A MorrisonJessica E Treisman

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